دورية أكاديمية
The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity
| العنوان: | The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity |
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| المؤلفون: | Hakim, Olah, Bello, Oluwatoyosi, Ladwa, Meera, Peacock, Janet L, Umpleby, A Margot, Charles-Edwards, Geoffrey, Amiel, Stephanie A, Goff, Louise M |
| المصدر: | Hakim , O , Bello , O , Ladwa , M , Peacock , J L , Umpleby , A M , Charles-Edwards , G , Amiel , S A & Goff , L M 2020 , ' The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity ' , Nutrients , vol. 12 , no. 12 . https://doi.org/10.3390/nu12123796Test |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adiponectin/blood, Adipose Tissue/diagnostic imaging, Adolescent, Adult, African Continental Ancestry Group/statistics & numerical data, Aged, Biomarkers/analysis, Body Fat Distribution, Cross-Sectional Studies, Diabetes Mellitus, Type 2/ethnology, European Continental Ancestry Group/statistics & numerical data, Humans, Inflammation Mediators/blood, Magnetic Resonance Imaging, Male, Middle Aged, Obesity/blood, Young Adult |
| الوصف: | In this study, we aimed to assess ethnic differences in visceral (VAT), deep subcutaneous (dSAT), and superficial subcutaneous (sSAT) adipose tissue and their relationships with inflammatory markers between white European (WE) and black West African (BWA) men with normal glucose tolerance (NGT) and type 2 diabetes (T2D). Forty-two WE (23 NGT/19 T2D) and 43 BWA (23 NGT/20 T2D) men underwent assessment of plasma inflammatory markers using immunoassays alongside Dixon magnetic resonance imaging to quantify L4-5 VAT, dSAT and sSAT. Despite no ethnic differences in sSAT and dSAT, BWA men exhibited lower VAT (p = 0.002) and dSAT:sSAT (p = 0.047) than WE men. Adiponectin was inversely associated with sSAT in WE (p = 0.041) but positively associated in BWA (p = 0.031) men with T2D. Interleukin-6 (IL-6) was associated with VAT in WE but not in BWA men with NGT (WE: p = 0.009, BWA: p = 0.137) and T2D (WE: p = 0.070, BWA: p = 0.175). IL-6 was associated with dSAT in only WE men with NGT (WE: p = 0.030, BWA: p = 0.833). The only significant ethnicity interaction present was for the relationship between adiponectin and sSAT (Pinteraction = 0.003). The favourable adipose tissue distribution and the weaker relationships between adiposity and inflammation in BWA men suggest that adipose tissue inflammation may play a lesser role in T2D in BWA than WE men. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3390/nu12123796 |
| الإتاحة: | https://doi.org/10.3390/nu12123796Test https://pure.roehampton.ac.uk/portal/en/publications/0ab84ac7-50ec-4dcb-9312-0c951ec7a739Test https://pure.roehampton.ac.uk/ws/files/6092607/Hakim_et_al._2020_nutrients.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.88F01EFF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu12123796 |
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