التفاصيل البيبلوغرافية
| العنوان: |
A Comprehensive Landscape for Fibril Association Behaviors Encoded Synergistically by Saccharides and Peptides |
| المؤلفون: |
Rongying Liu (8194986), Ran Zhang (117374), Long Li (6555), Zdravko Kochovski (1397407), Lintong Yao (6372974), Mu-Ping Nieh (1473517), Yan Lu (32611), Tongfei Shi (1674556), Guosong Chen (1397413) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Physiology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, building blocks, model building blocks, glycopeptide building blocks, macroscopic properties, Fibril Association Behaviors Encode., fibril association |
| الوصف: |
Nature provides us a panorama of fibrils with tremendous structural polymorphism from molecular building blocks to hierarchical association behaviors. Despite recent achievements in creating artificial systems with individual building blocks through self-assembly, molecularly encoding the relationship from model building blocks to fibril association, resulting in controlled macroscopic properties, has remained an elusive goal. In this paper, by employing a designed set of glycopeptide building blocks and combining experimental and computational tools, we report a library of controlled fibril polymorphism with elucidation from molecular packing to fibril association and the related macroscopic properties. The growth of the fibril either axially or radially with right- or left-handed twisting is determined by the subtle trade-off of oligosaccharide and oligopeptide components. Meanwhile, visible evidence for the association process of double-strand fibrils has been experimentally and theoretically proposed. Finally the fibril polymorphs demonstrated significant different macroscopic properties on hydrogel formation and cellular migration control. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/A_Comprehensive_Landscape_for_Fibril_Association_Behaviors_Encoded_Synergistically_by_Saccharides_and_Peptides/14488989Test |
| DOI: |
10.1021/jacs.1c01951.s001 |
| الإتاحة: |
https://doi.org/10.1021/jacs.1c01951.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.88DE8E4E |
| قاعدة البيانات: |
BASE |
