دورية أكاديمية
Synucleinopathies Take Their Toll: Are TLRs a Way to Go?
| العنوان: | Synucleinopathies Take Their Toll: Are TLRs a Way to Go? |
|---|---|
| المؤلفون: | Gabriella M. Mazzotta, Nadia Ceccato, Carmela Conte |
| المساهمون: | Mazzotta, Gabriella M., Ceccato, Nadia, Conte, Carmela |
| سنة النشر: | 2023 |
| المجموعة: | IRIS Università degli Studi di Perugia |
| مصطلحات موضوعية: | Alpha-synucleinopathie, Toll-like receptor, non-motor symptoms |
| الوصف: | The misfolding and subsequent abnormal accumulation and aggregation of -Synuclein ( Syn) as insoluble fibrils in Lewy bodies and Lewy neurites is the pathological hallmark of Parkinson’s disease (PD) and several neurodegenerative disorders. A combination of environmental and genetic factors is linked to Syn misfolding, among which neuroinflammation is recognized to play an important role. Indeed, a number of studies indicate that a Toll-like receptor (TLR)-mediated neuroinflammation might lead to a dopaminergic neural loss, suggesting that TLRs could participate in the pathogenesis of PD as promoters of immune/neuroinflammatory responses. Here we will summarize our current understanding on the mechanisms of Syn aggregation and misfolding, focusing on the contribution of TLRs to the progression of -synucleinopathies and speculating on their link with the non-motor disturbances associated with aging and neurodegenerative disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37174631; info:eu-repo/semantics/altIdentifier/wos/WOS:000986876300001; volume:XII; firstpage:1231; lastpage:1243; numberofpages:13; journal:CELLS; https://hdl.handle.net/11391/1549213Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85159207584; https://www.mdpi.com/2073-4409/12/9/1231Test |
| DOI: | 10.3390/cells12091231 |
| الإتاحة: | https://doi.org/10.3390/cells12091231Test https://hdl.handle.net/11391/1549213Test https://www.mdpi.com/2073-4409/12/9/1231Test |
| رقم الانضمام: | edsbas.88698EFD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cells12091231 |
|---|