دورية أكاديمية
Attenuated androgen discontinuation in patients with hereditary angioedema: a commented case series.
| العنوان: | Attenuated androgen discontinuation in patients with hereditary angioedema: a commented case series. |
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| المؤلفون: | Maurer, M., Magerl, M., Aygören-Pürsün, E., Bork, K., Farkas, H., Longhurst, H., Kiani-Alikhan, S., Bouillet, Laurence, Boccon-Gibod, Isabelle, Cancian, M., Zanichelli, A., Launay, David |
| المساهمون: | Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Centre de référence national des angiœdèmes (CREAK), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Université Grenoble Alpes (UGA), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) |
| المصدر: | ISSN: 1710-1484. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2022 |
| المجموعة: | LillOA (HAL Lille Open Archive, Université de Lille) |
| مصطلحات موضوعية: | Angioedema, hereditary, Prophylaxis, Attenuated androgens, Danazol, Oxandrolone, Case series, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; BackgroundHereditary angioedema (HAE) is characterized by potentially severe and life-threatening attacks of localized swelling. Prophylactic therapies are available, including attenuated androgens. Efficacy of attenuated androgens has not been assessed in large, randomized, placebo-controlled trials and can be associated with frequent, and sometimes severe, side effects. As better tolerated targeted therapies become available, attenuated androgen withdrawal is increasingly considered by physicians and their patients with HAE. Attenuated androgens withdrawal has not been systematically studied in HAE, although examination of other disorders indicates that attenuated androgen withdrawal may result in mood disturbances and flu-like symptoms. Standardized protocols for attenuated androgen discontinuation that continue to provide control of attacks while limiting potential attenuated androgen withdrawal symptoms are not established as the outcomes of different withdrawal strategies have not been compared. We aim to describe the challenges of attenuated androgen discontinuation in patients with HAE and how these may continue into the post-androgen period.Case presentationWe present a retrospective case series of 10 patients with confirmed type I HAE who have discontinued prophylactic treatment with attenuated androgens. The most common reason for attenuated androgen discontinuation was side effects. Attenuated androgens were either immediately withdrawn, tapered and/or overlapped with another treatment. The major challenge of discontinuation was the management of an increased frequency and severity of HAE attacks in some patients.ConclusionsHealthcare teams need to undertake careful planning and monitoring after attenuated androgens discontinuation, and modify treatment strategies if HAE control is destabilized with an increased number of attacks. Discontinuation of attenuated androgens is definitively an option in an evolving HAE treatment landscape, and outcomes can be favourable with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35027083; hal-04496237; https://hal.univ-lille.fr/hal-04496237Test; https://hal.univ-lille.fr/hal-04496237/documentTest; https://hal.univ-lille.fr/hal-04496237/file/s13223-021-00644-0.pdfTest; PUBMED: 35027083 |
| DOI: | 10.1186/s13223-021-00644-0 |
| الإتاحة: | https://doi.org/10.1186/s13223-021-00644-0Test https://hal.univ-lille.fr/hal-04496237Test https://hal.univ-lille.fr/hal-04496237/documentTest https://hal.univ-lille.fr/hal-04496237/file/s13223-021-00644-0.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.8863F08B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13223-021-00644-0 |
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