دورية أكاديمية
Conservative versus surgical treatment of foot drop in peroneal nerve entrapment: rationale and design of a prospective, multi-centre, randomized parallel-group controlled trial
| العنوان: | Conservative versus surgical treatment of foot drop in peroneal nerve entrapment: rationale and design of a prospective, multi-centre, randomized parallel-group controlled trial |
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| المؤلفون: | Oosterbos, C., Rummens, S., Bogaerts, K., Hoornaert, S., Weyns, F., Dubuisson, Annie, Lemmens, R., Theys, T. |
| المصدر: | Trials, 23 (1) (2022) |
| بيانات النشر: | BioMed Central Ltd |
| سنة النشر: | 2022 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Conservative treatment, Foot drop, Neurolysis, Peroneal nerve, Protocol design, Randomized controlled trial, adult, ankle dorsiflexion angle, Article, clinical feature, comparative effectiveness, controlled study, European Quality of Life 5 Dimensions 5 Level questionnaire, female, functional status, human, major clinical study, male, multicenter study, nerve compression, nerve decompression, patient-reported outcome, peroneal nerve entrapment, peroneus nerve paralysis, prospective study, risk factor, six minute walk test, ten minute walk test, walk test, ankle |
| الوصف: | peer reviewed ; Background: High-quality evidence is lacking to support one treatment strategy over another in patients with foot drop due to peroneal nerve entrapment. This leads to strong variation in daily practice. Methods/design: The FOOTDROP (Follow-up and Outcome of Operative Treatment with Decompressive Release Of The Peroneal nerve) trial is a randomized, multi-centre study in which patients with peroneal nerve entrapment and persistent foot drop, despite initial conservative treatment, will be randomized 10 (± 4) weeks after onset between non-invasive treatment and surgical decompression. The primary endpoint is the difference in distance covered during the 6-min walk test between randomization and 9 months later. Time to recovery is the key secondary endpoint. Other secondary outcome measures encompass ankle dorsiflexion strength (MRC score and isometric dynamometry), gait assessment (10-m walk test, functional ambulation categories, Stanmore questionnaire), patient-reported outcome measures (EQ5D-5L), surgical complications, neurological deficits (sensory changes, motor scores for ankle eversion and hallux extension), health economic assessment (WPAI) and electrodiagnostic assessment. Discussion: The results of this randomized trial may elucidate the role of surgical decompression of the peroneal nerve and aid in clinical decision-making. Trial registration: ClinicalTrials.gov NCT04695834. Registered on 4 January 2021. © 2022, The Author(s). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1745-6215 |
| العلاقة: | urn:issn:1745-6215; https://orbi.uliege.be/handle/2268/303696Test; info:hdl:2268/303696; https://orbi.uliege.be/bitstream/2268/303696/1/Conservative%20versus%20surgical%20treatment%20of%20foot%20drop.pdfTest; scopus-id:2-s2.0-85145123717; info:pmid:36581937 |
| DOI: | 10.1186/s13063-022-07009-x |
| الإتاحة: | https://doi.org/10.1186/s13063-022-07009-xTest https://orbi.uliege.be/handle/2268/303696Test https://orbi.uliege.be/bitstream/2268/303696/1/Conservative%20versus%20surgical%20treatment%20of%20foot%20drop.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8806909 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17456215 |
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| DOI: | 10.1186/s13063-022-07009-x |