تقرير
Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4
| العنوان: | Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4 |
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| المؤلفون: | Du J, Fan YL, Guo Z, Wang YG, Zheng X(郑旭), Huang C, Liang BH, Gao LY, Cao YP, Chen YP, Zhang X, Li L, Xu LP, Wu CY, Weitz DA, Feng XQ |
| المساهمون: | Du, Jing, Weitz, David A., Feng, Xiqiao |
| سنة النشر: | 2019 |
| المجموعة: | IMECH-IR (Institute of Mechanics, Chinese Academy of Sciences) / 中国科学院力学研究所机构知识库 |
| مصطلحات موضوعية: | RHO-ASSOCIATED KINASE, MYOSIN, PHOSPHORYLATION, MECHANICS, STIFFNESS, FRET, Biochemistry & Molecular Biology, Cell Biology, 一类 |
| الوصف: | Mechanical factors play critical roles in mammalian development. Here, we report that colony-growing mouse embryonic stem cells (mESCs) generate significant tension on the colony surface through the contraction of a three-dimensional supracellular actomyosin cortex (3D-SAC). Disruption of the 3D-SAC, whose organization is dependent on the Rho/Rho-associated kinase (ROCK) signals and E-cadherin, results in mESC colony destruction. Reciprocally, compression force, which is generated by the 3D-SAC, promotes colony growth and expression of Nanog and Oct4 in mESCs and blastocyst development of mouse embryos. These findings suggest that autonomous cell forces regulate embryonic stem cells fate determination and provide insight regarding the biomechanical regulation of embryonic development. |
| نوع الوثيقة: | report |
| اللغة: | English |
| العلاقة: | CELL SYSTEMS; http://dspace.imech.ac.cn/handle/311007/79937Test; http://dspace.imech.ac.cn/handle/311007/79938Test |
| DOI: | 10.1016/j.cels.2019.05.008 |
| الإتاحة: | https://doi.org/10.1016/j.cels.2019.05.008Test http://dspace.imech.ac.cn/handle/311007/79937Test http://dspace.imech.ac.cn/handle/311007/79938Test |
| رقم الانضمام: | edsbas.87E1C2E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cels.2019.05.008 |
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