دورية أكاديمية
Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus
| العنوان: | Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus |
|---|---|
| المؤلفون: | Xu, Hao, Wang, Zhanxiang, Zhang, Shaolin, Tan, Guowei, Zhu, Hongwei, 王占祥, 谭国伟 |
| المصدر: | http://dx.doi.org/10.3171/2013.2.PEDS12324Test. |
| بيانات النشر: | AMER ASSOC NEUROLOGICAL SURGEONS |
| سنة النشر: | 2013 |
| المجموعة: | Xiamen University Institutional Repository |
| مصطلحات موضوعية: | CHRONIC HEPATITIS-B, H-TX RAT, SUBARACHNOID HEMORRHAGE, POSTHEMORRHAGIC HYDROCEPHALUS, FIBROSIS, BRAIN, MODEL, OBSTRUCTION, EXPRESSION, INDUCTION |
| الوصف: | Natural Science Foundation of China [81271332] ; Object. Fibrosis along the route of CSF flow is indicated by the development of hydrocephalus. The changes of fibrosis index might reflect the level of hydrocephalus and even become a diagnostic index of hydrocephalus. The object of this study was to analyze the levels of procollagen Type I C-terminal propeptide (PICP), procollagen Type III N-terminal propeptide (PIIINP), hyaluronic acid (HA), and laminin (LN) and their significance in the CSF of communicating hydrocephalus rat models. Methods. Thirty adult Sprague-Dawley rats were randomly divided into 3 groups: hydrocephalus group (20 rats) with intraventricular kaolin injections, sham control group (5 rats) with saline injections, and normal group (5 rats) without any processing. The levels of PICP, PIIINP, HA, and LN in the CSF were detected using ELISA. Results. Levels of PICP, PIIINP, HA, and LN in the hydrocephalus group were significantly higher than those in the saline control group (p < 0.05). It was revealed by correlation analysis that the increase was positively correlated with the severity of ventricular dilation. Conclusions. Results indicated that PICP, PIIINP, HA, and LN continue to rise dramatically in experimental hydrocephalus and may serve as the diagnostic index of hydrocephalus. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | JOURNAL OF NEUROSURGERY-PEDIATRICS, 2013,11(6):692-696; WOS:000319366900013; http://dspace.xmu.edu.cn/handle/2288/93539Test |
| الإتاحة: | https://doi.org/10.3171/2013.2.PEDS12324Test http://dspace.xmu.edu.cn/handle/2288/93539Test |
| رقم الانضمام: | edsbas.87D72149 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |