دورية أكاديمية
Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats
| العنوان: | Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats |
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| المؤلفون: | Laker, Rhianna C., Gallo, Linda A., Wlodek, Mary E., Siebel, Andrew L., Wadley, Glenn D., McConell, Glenn K. |
| بيانات النشر: | American Physiological Society |
| سنة النشر: | 2011 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | β-Cell, Fetal size, Insulin secretion, beta-Cell, 1314 Physiology, 2712 Endocrinology, Diabetes and Metabolism, 2737 Physiology (medical) |
| الوصف: | Fetal growth restriction is associated with reduced pancreatic β-cell mass, contributing to impaired glucose tolerance and diabetes. Exercise training increases β -cell mass in animals with diabetes and has long-lasting metabolic benefits in rodents and humans. We studied the effect of exercise training on islet and β -cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted in Restricted offspring born small compared with shamoperated Controls and also sham-operated Reduced litter offspring that had their litter size reduced to five pups at birth. Restricted, Control, and Reduced litter offspring remained sedentary or underwent treadmill running from 5 to 9 or 20 to 24 wk of age. Early life exercise increased relative islet surface area and β -cell mass across all groups at 9 wk, partially restoring the 60-68% deficit (P < 0.05) in Restricted offspring. Remarkably, despite no further exercise training after 9 wk, β -cell mass was restored in Restricted at 24 wk, while sedentary littermates retained a 45% deficit (P < 0.05) in relative β -cell mass. Later exercise training also restored Restricted β -cell mass to Control levels. In conclusion, early life exercise training in rats born small restored β -cell mass in adulthood and may have beneficial consequences for later metabolic health and disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0193-1849 1522-1555 |
| العلاقة: | orcid:0000-0002-0471-8517; 454570 |
| الإتاحة: | https://doi.org/10.1152/ajpendo.00114.2011Test https://espace.library.uq.edu.au/view/UQ:323082Test |
| رقم الانضمام: | edsbas.87D54A04 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 01931849 15221555 |
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