دورية أكاديمية
Triglycerides glucose index and high-sensitivity C-reactive protein are predictors of outcome in chronic coronary syndrome
| العنوان: | Triglycerides glucose index and high-sensitivity C-reactive protein are predictors of outcome in chronic coronary syndrome |
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| المؤلفون: | Neglia, D, Aimo, A, Caselli, C, Gimelli, A |
| المصدر: | European Heart Journal - Cardiovascular Imaging ; volume 22, issue Supplement_3 ; ISSN 2047-2404 2047-2412 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging, General Medicine |
| الوصف: | Funding Acknowledgements Type of funding sources: None. Background It is unknown whether insulin resistance (IR) and inflammation identify residual prognostic risk in patients with chronic coronary syndrome (CCS). Aims To assess whether the triglyceride-glucose (TyG) index and high-sensitivity C-reactive protein (hs-CRP) are independent predictors of outcome in CCS. Methods TyG index and hs-CRP were evaluated in 1097 consecutive patients (75% men, median age 72 years) with known (26%) or suspected coronary artery disease (CAD) undergoing stress-rest myocardial perfusion scintigraphy (MPS) and coronary angiography and followed-up for a median of 4.5-year. Results Moderate/severe perfusion abnormalities during stress were documented in 60% of patients, obstructive CAD in 74%, and 36% underwent early revascularization. TyG index was 8.9 (median, interquartile interval 8.6-9.2) and of hs-CRP was 0.3 mg/L (0.1-0.8). Cardiac death or myocardial infarction occurred in 103 patients and all-cause death in 65. Patients in the fourth TyG quartile (TyG ≥ 9.2), with hs-CRP ≥ 2 mg/L or with both had the shortest survival free from cardiac events or all-cause death. TyG predicted cardiac events (HR 2.46, 95% CI 1.59-3.79, p < 0.001) and all-cause death (HR 3.64, 95% CI 2.22-5.96, p < 0.001) independently of other risk factors, perfusion abnormalities or obstructive CAD. Hs-CRP was also an independent predictor of all-cause death (HR 1.11, 95% CI 1.04-1.19, p = 0.002) and reclassified the risk over the other variables and TyG (IDI 0.05, 95% CI 0.01-0.07, p = 0.005). Conclusions The TyG index identifies a high residual risk of cardiac events in patients with CCS. The TyG index and hs-CRP are strong and interacting predictors of all-cause death. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ehjci/jeab111.043 |
| الإتاحة: | https://doi.org/10.1093/ehjci/jeab111.043Test http://academic.oup.com/ehjcimaging/article-pdf/22/Supplement_3/jeab111.043/39199342/jeab111.043.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.87AA8057 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjci/jeab111.043 |
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