دورية أكاديمية
Long-Term Efficacy and Safety of Anlotinib as a Monotherapy and Combined Therapy for Advanced Sarcoma
| العنوان: | Long-Term Efficacy and Safety of Anlotinib as a Monotherapy and Combined Therapy for Advanced Sarcoma |
|---|---|
| المؤلفون: | Yao,Weitao, Du,Xinhui, Wang,Jiaqiang, Wang,Xin, Zhang,Peng, Niu,Xiaohui |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2022 |
| المجموعة: | Dove Medical Press |
| مصطلحات موضوعية: | OncoTargets and Therapy |
| الوصف: | Weitao Yao,1 Xinhui Du,1 Jiaqiang Wang,1 Xin Wang,1 Peng Zhang,1 Xiaohui Niu2 1Bone and Soft Department, The Affiliated Cancer Hospital of Zheng Zhou University, He Nan Cancer Hospital, Zheng Zhou City, 450000, People’s Republic of China; 2Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, Beijing, 100035, People’s Republic of ChinaCorrespondence: Weitao Yao, Bone and Soft Department, The Affiliated Cancer Hospital of Zheng Zhou University, He Nan Cancer Hospital, 127 Dong Ming Road, Zheng Zhou City, 450000, People’s Republic of China, Email ywtwhm@163.com Xiaohui Niu, Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, No. 31 Xin Jie Kou Dong Jie, Xi Cheng District, Beijing, 100035, People’s Republic of China, Email niuxiaohui@263.netObjective: To analyze the effectiveness of the long-term (> 12 months) administration of anlotinib as a monotherapy or combined therapy in patients with advanced sarcomas.Methods: A retrospective analysis was conducted of patients with advanced sarcomas with measurable target lesions since 2018. Twenty-two of the patients had taken anlotinib regularly for > 12 months. The patients’ general information and the drug’s clinical efficacy and toxicity data were collected and statistically analyzed using RECIST 1.1 to measure the target lesions and tumor PFS time as the main endpoints. We used a swimmer plot to observe the drug’s efficacy and duration, and employed a waterfall plot to express the best treatment effect.Results: The study included 14 male and 8 female patients, ranging in age from 14 to 75 (mean: 44.82) years. The primary diseases included alveolar soft part sarcoma, synovial sarcoma, leiomyosarcoma, and others. The metastasis sites were the lungs in fifteen cases, lymph nodes in four cases, and multiple sites in three cases. Fourteen patients had previously undergone chemotherapy. The current therapy protocol was oral anlotinib alone for nine cases, combination ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/long-term-efficacy-and-safety-of-anlotinib-as-a-monotherapy-and-combin-peer-reviewed-fulltext-article-OTTTest |
| الإتاحة: | https://doi.org/10.2147/OTT.S365506Test https://www.dovepress.com/long-term-efficacy-and-safety-of-anlotinib-as-a-monotherapy-and-combin-peer-reviewed-fulltext-article-OTTTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8777C925 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |