دورية أكاديمية
A gene variation (rs12691) in the CCAT/enhancer binding protein alpha modulates glucose metabolism in metabolic syndrome
| العنوان: | A gene variation (rs12691) in the CCAT/enhancer binding protein alpha modulates glucose metabolism in metabolic syndrome |
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| المؤلفون: | Delgado-Lista, J., Perez-Martinez, P., García-Ríos, A., Phillips, C. M., Hall, W., Gjelstad, I. M. F., Lairon, Denis, Saris, W., Kiec-Wilk, B., Karlstrom, B., Drevon, C. A., Defoort, Catherine, Blaak, E. E., Dembinska-Kiec, A., Riserus, U., Lovegrove, J. A., Roche, H. M., Lopez-Miranda, J. |
| المساهمون: | Universidad de Córdoba = University of Córdoba Córdoba, CIBER Fisiopatol Obesidad & Nutr CIBERobn, University College Dublin (UCD), University of Reading (UOR), University of Oslo (UiO), Oslo University Hospital Oslo, Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Maastricht University Maastricht, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Uppsala University, LIPGENE - an European Union FOOD-CT-2003-505944, Spanish Ministry of Science and Innovation AGL 2004-07907, AGL2006-01979, AGL2009-12270, SAF07-62005, FIS PI10/01041, PI10/02412, Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion de Excelencia, Junta de Andalucia P06-CTS-01425, CTS5015, AGR922, Consejeria de Salud, Junta de Andalucia 06/128, 07/43, PI0193/09, 06/129, 06/127, 0118/08, PI-0252/09, PI-0058/10 |
| المصدر: | ISSN: 0939-4753 ; Nutrition, Metabolism and Cardiovascular Diseases ; https://hal.inrae.fr/hal-02647389Test ; Nutrition, Metabolism and Cardiovascular Diseases, 2013, 23 (5), pp.417 - 423. ⟨10.1016/j.numecd.2011.09.008⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | CEBP alpha, C/EBP alpha, insulin secretion, insulin resistance, C/EBP-ALPHA, ADIPOCYTE DIFFERENTIATION, LIPGENE, Metabolic syndrome, ACUTE MYELOID-LEUKEMIA, CELL, TRANSCRIPTION, EXPRESSION, VARIANTS, MAX, MEN, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background and aims: CCAAT/enhancer-binding protein alpha (CEBPA) is a transcription factor involved in adipogenesis and energy homeostasis. Caloric restriction reduces CEBPA protein expression in patients with metabolic syndrome (MetS). A previous report linked rs12691 SNP in CEBPA to altered concentration of fasting triglycerides. Our objective was to assess the effects of rs12691 in glucose metabolism in Metabolic Syndrome (MetS) patients. Methods and results: Glucose metabolism was assessed by static (glucose, insulin, adiponectin, leptin and resistin plasma concentrations) and dynamic (disposition index, insulin sensitivity index, HOMA-IR and acute insulin response to glucose) indices, performed at baseline and after 12 weeks of 4 dietary interventions (high saturated fatty acid (SFA), high monounsaturated fatty acid (MUFA), low-fat and low-fat-high-n3 polyunsaturated fatty acid (PUFA)) in 486 subjects with MetS. Carriers of the minor A allele of rs12691 had altered disposition index (p = 0.0003), lower acute insulin response (p = 0.005) and a lower insulin sensitivity index (p = 0.025) indicating a lower insulin sensitivity and a lower insulin secretion, at baseline and at the end of the diets. Furthermore, A allele carriers displayed lower HDL concentration. Conclusion: The presence of the A allele of rs12691 influences glucose metabolism of MetS patients. Clinical Trials Registry number NCT00429195. (C) 2011 Elsevier B.V. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-02647389; https://hal.inrae.fr/hal-02647389Test; PRODINRA: 208642; WOS: 000319337600008 |
| DOI: | 10.1016/j.numecd.2011.09.008 |
| الإتاحة: | https://doi.org/10.1016/j.numecd.2011.09.008Test https://hal.inrae.fr/hal-02647389Test |
| رقم الانضمام: | edsbas.871A3BBD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.numecd.2011.09.008 |
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