التفاصيل البيبلوغرافية
| العنوان: |
Effects of Meloxicam and Phenylbutazone on Equine Gastric Mucosal Permeability |
| المؤلفون: |
D'Arcy‐Moskwa, E., Noble, G.K., Weston, L.A., Boston, R., Raidal, S.L. |
| المصدر: |
Journal of Veterinary Internal Medicine ; volume 26, issue 6, page 1494-1499 ; ISSN 0891-6640 1939-1676 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2012 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background Newer NSAID s that more selectively target the induced isoform of the cyclooxygenase enzyme ( COX 2) activity might reduce adverse effects while preserving therapeutic benefits of these drugs. Objectives To compare the effect of oral administration of multiple dose rates of meloxicam and phenylbutazone ( PBZ ) on gastric mucosal integrity in horses. Animals Twenty‐five light breed horses. Methods In vivo toxicity study. Horses were randomly assigned to 5 treatment groups, receiving placebo, PBZ (4.4 mg/kg PO q12h day 1, 2.2 mg/kg PO q12h for 4 days, 2.2 mg/kg PO q24h for 9 days), or 3 dose rates of meloxicam (0.6 mg/kg q24h, 1.8 mg/kg q24h, 3.0 mg/kg q24h) for 14 days. Sucrose permeability testing was performed on Day 0 (before treatment) and on Day 13. All personnel involved with data collection or analysis were blinded to treatment. Results Administration of PBZ at the above dose rate significantly increased gastric permeability to sucrose, evidenced by increased peak serum sucrose concentrations (280–1,580 pg/μL, P = .001) after treatment. Similar changes were not evident after administration of meloxicam at any dose rate tested, or in control horses ( P > .05). Treatment was not associated with significant differences in ulceration of the squamous or glandular mucosa. Peak sucrose concentrations were not correlated with serum total protein or albumin concentrations (R 2 = −0.07, P = .61, R 2 = −0.08, P = .58, respectively). Conclusion and Clinical Importance These results suggest that PBZ was associated with greater compromise to gastric mucosal integrity than meloxicam. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1939-1676.2012.01004.x |
| الإتاحة: |
https://doi.org/10.1111/j.1939-1676.2012.01004.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.8706E52C |
| قاعدة البيانات: |
BASE |
