التفاصيل البيبلوغرافية
| العنوان: |
Cell Development—A Dynamic Simulator for Closed-Loop Control with Hardware-in-the-Loop |
| المؤلفون: |
Eyal Dassau, Ph. D, Cesar C. Palerm, Howard Zisser, Bruce A. Buckingham, Francis J. Doyle Iii |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://www.myomnipod.com/pdf/DiabetesTest Tech Therapertics March 2009.pdf. |
| المجموعة: |
CiteSeerX |
| الوصف: |
Background: A critical step in algorithm development for an artificial -cell is extensive in silico testing. Com-puter simulations usually involve only the controller software, leaving untested the hardware elements, in-cluding the critical communication interface between the controller and the glucose sensor and insulin pump. Methods: An in silico simulation platform has been developed that uses all of the components of the clinical system. At the core is a comprehensive in silico population model that covers the variability of principal meta-bolic parameters observed in vivo, to replace the human subject, with the ability to use historical clinical data. A continuous glucose monitor, in this case either the Abbott Diabetes Care (Alameda, CA) FreeStyle Naviga-tor ® or the DexCom (San Diego, CA) STS7®, is supplied with a glucose signal provided by the simulator. The Insulet (Bedford, MA) OmniPod ® insulin pump is also interfaced with the simulator to provide insulin deliv-ery data. These hardware elements are an integral part of the system under testing, which also includes the al-gorithm components. Results: The system is unique in that it uses the same hardware components for simulations as are required in clinical trials, allowing for full-system level verification and validation. With a detailed mathematical model, a suite of patients can be simulated to reflect various conditions. Because all hardware is used, their related lim-itations are automatically included. Conclusions: A complete artificial -cell evaluation platform was realized with the flexibility to interface vari-ous algorithms and patient models, allowing for the systematic analysis of monitoring and control algorithms. The system facilitates a variety of tests and challenges to the software and the component devices, streamlin-ing preclinical validation trials. 187 |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.9069Test; http://www.myomnipod.com/pdf/DiabetesTest Tech Therapertics March 2009.pdf |
| الإتاحة: |
http://www.myomnipod.com/pdf/DiabetesTest Tech Therapertics March 2009.pdf |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.86C5F84D |
| قاعدة البيانات: |
BASE |
