دورية أكاديمية
Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease
| العنوان: | Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease |
|---|---|
| المؤلفون: | Shirzadi, Z, Schultz, SA, Yau, WYW, Joseph-Mathurin, N, Fitzpatrick, CD, Levin, R, Kantarci, K, Preboske, GM, Jack, CR, Farlow, MR, Hassenstab, J, Jucker, M, Morris, JC, Xiong, C, Karch, CM, Levey, AI, Gordon, BA, Schofield, PR, Salloway, SP, Perrin, RJ, McDade, E, Levin, J, Cruchaga, C, Allegri, RF, Fox, NC, Goate, A, Day, GS, Koeppe, R, Chui, HC, Berman, S, Mori, H, Sanchez-Valle, R, Lee, JH, Rosa-Neto, P, Ruthirakuhan, M, Wu, CY, Swardfager, W, Benzinger, TLS, Sohrabi, HR, Martins, RN, Bateman, RJ, Johnson, KA, Sperling, RA, Greenberg, SM, Schultz, AP, Chhatwal, JP |
| المصدر: | JAMA Neurology , 80 (12) pp. 1353-1363. (2023) |
| بيانات النشر: | American Medical Association |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | IMPORTANCE: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains unclear whether increased WMH along the AD continuum is reflective of AD-intrinsic processes or secondary to elevated systemic vascular risk factors. OBJECTIVE: To estimate the associations of neurodegeneration and parenchymal and vessel amyloidosis with WMH accumulation and investigate whether systemic vascular risk is associated with WMH beyond these AD-intrinsic processes. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from 3 longitudinal cohort studies conducted in tertiary and community-based medical centers—the Dominantly Inherited Alzheimer Network (DIAN; February 2010 to March 2020), the Alzheimer’s Disease Neuroimaging Initiative (ADNI; July 2007 to September 2021), and the Harvard Aging Brain Study (HABS; September 2010 to December 2019). MAIN OUTCOME MEASURES: The main outcomes were the independent associations of neurodegeneration (decreases in gray matter volume), parenchymal amyloidosis (assessed by amyloid positron emission tomography), and vessel amyloidosis (evidenced by cerebral microbleeds [CMBs]) with cross-sectional and longitudinal WMH. RESULTS: Data from 3960 MRI sessions among 1141 participants were included: 252 pathogenic variant carriers from DIAN (mean [SD] age, 38.4 [11.2] years; 137 [54%] female), 571 older adults from ADNI (mean [SD] age, 72.8 [7.3] years; 274 [48%] female), and 318 older adults from HABS (mean [SD] age, 72.4 [7.6] years; 194 [61%] female). Longitudinal increases in WMH volume were greater in individuals with CMBs compared with those without (DIAN: t = 3.2 [P = .001]; ADNI: t = 2.7 [P = .008]), associated with longitudinal decreases in gray matter volume (DIAN: t = −3.1 [P = .002]; ADNI: t = −5.6 [P < .001]; HABS: t = −2.2 [P = .03]), greater in older individuals (DIAN: t = 6.8 [P < .001]; ADNI: t = 9.1 [P < .001]; HABS: ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10185441/2/Fox_Etiology%20of%20White%20Matter%20Hyperintensities%20in%20Autosomal%20Dominant%20and%20Sporadic%20Alzheimer%20Disease_AAM.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10185441Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10185441/2/Fox_Etiology%20of%20White%20Matter%20Hyperintensities%20in%20Autosomal%20Dominant%20and%20Sporadic%20Alzheimer%20Disease_AAM.pdfTest https://discovery.ucl.ac.uk/id/eprint/10185441Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.864D82B3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |