دورية أكاديمية
OPA1 drives macrophage metabolism and functional commitment via p65 signaling
| العنوان: | OPA1 drives macrophage metabolism and functional commitment via p65 signaling |
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| المؤلفون: | Sánchez-Rodríguez, Ricardo, Tezze, Caterina, Agnellini, Andrielly H. R., Angioni, Roberta, Venegas, Francisca C., Cioccarelli, Chiara, Munari, Fabio, Bertoldi, Nicole, Canton, Marcella, Desbats, Maria Andrea, Salviati, Leonardo, Gissi, Rosanna, Castegna, Alessandra, Soriano, Maria Eugenia, Sandri, Marco, Scorrano, Luca, Viola, Antonella, Molon, Barbara |
| المصدر: | Cell Death & Differentiation ; volume 30, issue 3, page 742-752 ; ISSN 1350-9047 1476-5403 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cell Biology, Molecular Biology |
| الوصف: | Macrophages are essential players for the host response against pathogens, regulation of inflammation and tissue regeneration. The wide range of macrophage functions rely on their heterogeneity and plasticity that enable a dynamic adaptation of their responses according to the surrounding environmental cues. Recent studies suggest that metabolism provides synergistic support for macrophage activation and elicitation of desirable immune responses; however, the metabolic pathways orchestrating macrophage activation are still under scrutiny. Optic atrophy 1 (OPA1) is a mitochondria-shaping protein controlling mitochondrial fusion, cristae biogenesis and respiration; clear evidence shows that the lack or dysfunctional activity of this protein triggers the accumulation of metabolic intermediates of the TCA cycle. In this study, we show that OPA1 has a crucial role in macrophage activation. Selective Opa1 deletion in myeloid cells impairs M1-macrophage commitment. Mechanistically, Opa1 deletion leads to TCA cycle metabolite accumulation and defective NF-κB signaling activation. In an in vivo model of muscle regeneration upon injury, Opa1 knockout macrophages persist within the damaged tissue, leading to excess collagen deposition and impairment in muscle regeneration. Collectively, our data indicate that OPA1 is a key metabolic driver of macrophage functions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41418-022-01076-y |
| الإتاحة: | https://doi.org/10.1038/s41418-022-01076-yTest https://www.nature.com/articles/s41418-022-01076-y.pdfTest https://www.nature.com/articles/s41418-022-01076-yTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.864C67FD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41418-022-01076-y |
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