دورية أكاديمية
P15.08.B Intraoperative confocal laser endomicroscopy of brain tumors - potential and challenges from a neuropathological perspective
| العنوان: | P15.08.B Intraoperative confocal laser endomicroscopy of brain tumors - potential and challenges from a neuropathological perspective |
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| المؤلفون: | Maragkou, T, Quint, K, Pollo, B, Hewer, E |
| المصدر: | Neuro-Oncology ; volume 24, issue Supplement_2, page ii85-ii85 ; ISSN 1522-8517 1523-5866 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Neurology (clinical), Oncology |
| الوصف: | Background Intraoperative consultation, usually in the form of a frozen section, is an integral part of current neuropathology practice. Typical indications include determination of specimen adequacy, intraoperative diagnosis and distinction between tumoral and non-tumoral tissue in diffusely infiltrating gliomas in tumor periphery. The latter is currently limited by the fact that typically not all potential regions of interest can be sampled for frozen sections and the turnaround times of frozen sections usually do not permit multiple repetitive assessments. The commercial availability of a clinical-grade in vivo laser endomicroscope for neurosurgical applications may have the potential to change this and to permit a microscopic analysis in near-real time, which in turn may have a significant impact on resection strategies for brain tumors. In this work, we investigate the potential role of CLE in neurosurgery and the transferability of histological criteria to confocal imaging. Material and Methods The potential role of CLE in neurosurgery in comparison to other techniques for intraoperative tumor assessment was determined by analyzing common intraoperative neuropathological workflows and identifying unaddressed opportunities. The transferability of the histological criteria from standard histology to confocal imaging was achieved by analyzing matched image pairs (standard histology and CLE) from several common tumor entities. Results We identified the time gap between specimen resection and the availability of the frozen section results as an important application for intraoperative CLE imaging in neurosurgery. Importantly, neuropathologists could assess tissue in near real time in an unlimited number of digital biopsies prior to resection, which adds a potent new tool to the neurosurgical armamentarium. CLE images revealed features similar to already known tissue architecture/morphology seen in standard histology, which correlated well in matched histological images. Unique aspects of individual ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/neuonc/noac174.298 |
| الإتاحة: | https://doi.org/10.1093/neuonc/noac174.298Test https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_2/ii85/45691766/noac174.298.pdfTest |
| حقوق: | https://academic.oup.com/pages/standard-publication-reuse-rightsTest |
| رقم الانضمام: | edsbas.8628FCAB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/neuonc/noac174.298 |
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