دورية أكاديمية
Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma
| العنوان: | Myocardial Injury Is Associated with the Incidence of Major Adverse Cardiac Events in Patients with Severe Trauma |
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| المؤلفون: | Alexandra Stroda, Carina Jaekel, René M’Pembele, Alexander Guenther, Theresa Tenge, Carl Maximilian Thielmann, Simon Thelen, Erik Schiffner, Dan Bieler, Michael Bernhard, Ragnar Huhn, Giovanna Lurati Buse, Sebastian Roth |
| المصدر: | Journal of Clinical Medicine, Vol 11, Iss 7432, p 7432 (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | myocardial ischemia, cardiovascular complications, hemodynamics, prognosis, multiple trauma, Medicine |
| الوصف: | Background: Severe trauma potentially results in end-organ damage such as myocardial injury. Data suggest that myocardial injury is associated with increased mortality in this cohort, but the association with the incidence of in-hospital major adverse cardiac events (MACE) remains undetermined. Methods: Retrospective cohort study including adult patients with severe trauma treated at the University Hospital Duesseldorf between January 2016 and December 2019. The main exposure was myocardial injury at presentation. Endpoints were in-hospital incidence of MACE and incidence of acute kidney injury (AKI) within 72 h. Discrimination of hsTnT for MACE and AKI was examined by the receiver operating characteristic curve (ROC) and the area under the curve (AUC). We conducted multivariate logistic regression analysis. Results: We included 353 patients in our final analysis (72.5% male (256/353), age: 55 ± 21 years). The AUC for hsTnT and MACE was 0.68 [95% confidence interval (CI): 0.59–0.78]. The AUC for hsTnT and AKI was 0.64 [95% (CI): 0.55–0.72]. The adjusted odds ratio (OR) for myocardial injury and MACE was 2.97 [95% (CI): 1.31–6.72], and it was 2.14 [95% (CI): 1.03–4.46] for myocardial injury and AKI. Conclusion: Myocardial injury at presentation in patients with severe trauma is independently associated with the incidence of in-hospital MACE and AKI. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2077-0383 |
| العلاقة: | https://www.mdpi.com/2077-0383/11/24/7432Test; https://doaj.org/toc/2077-0383Test; https://doaj.org/article/5934a280b4f14950ae1c5de6b7d27e42Test |
| DOI: | 10.3390/jcm11247432 |
| الإتاحة: | https://doi.org/10.3390/jcm11247432Test https://doaj.org/article/5934a280b4f14950ae1c5de6b7d27e42Test |
| رقم الانضمام: | edsbas.85FE8CF9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20770383 |
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| DOI: | 10.3390/jcm11247432 |