دورية أكاديمية
Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes
العنوان: | Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes |
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المؤلفون: | Muscogiuri G., DeFronzo R. A., Gastaldelli A., Holst J. J. |
المساهمون: | Muscogiuri, G., Defronzo, R. A., Gastaldelli, A., Holst, J. J. |
سنة النشر: | 2016 |
المجموعة: | IRIS Università degli Studi di Napoli Federico II |
مصطلحات موضوعية: | appetite, central nervous system, glucagon-like peptide-1, neurodegenerative disease, type 2 diabete, Animal, Diabetes Mellitu, Diabetes Mellitus, Type 2, Glucagon-Like Peptide 1, Human, Peripheral Nervous System |
الوصف: | Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation of neurologic and cognitive functions. These actions are mediated via neurons in the nucleus of the solitary tract that project to multiple regions expressing GLP-1 receptors (GLP-1Rs). Treatment with GLP-1R agonists (GLP-1-RAs) reduces ischemia-induced hyperactivity, oxidative stress, neuronal damage and apoptosis, cerebral infarct volume, and neurologic damage, after cerebral ischemia, in experimental models. Ongoing human trials report a neuroprotective effect of GLP-1-RAs in Alzheimer's and Parkinson's disease. In this review, we discuss the role of GLP-1 and GLP-1-RAs in the nervous system with focus on GLP-1 actions on appetite regulation, glucose homeostasis, and neuroprotection. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000393018500002; volume:28; issue:2; firstpage:88; lastpage:103; numberofpages:16; journal:TRENDS IN ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/11588/880083Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85006048214 |
DOI: | 10.1016/j.tem.2016.10.001 |
الإتاحة: | https://doi.org/10.1016/j.tem.2016.10.001Test http://hdl.handle.net/11588/880083Test |
حقوق: | info:eu-repo/semantics/closedAccess |
رقم الانضمام: | edsbas.857B7C8E |
قاعدة البيانات: | BASE |
DOI: | 10.1016/j.tem.2016.10.001 |
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