دورية أكاديمية
Hippocampal atrophy in Systemic lupus erythematosus
| العنوان: | Hippocampal atrophy in Systemic lupus erythematosus |
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| المؤلفون: | Appenzeller, Simone, Carnevalle, Aline Daiane, Li, Li Min, Costallat, Lilian TL, Cendes, Fernando |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2006 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Extended Report |
| الوصف: | Objective: To determine the frequency and progression of hippocampal atrophy in systemic lupus erythematosus (SLE) and to determine clinical, laboratory and treatment features associated with its occurrence. Methods: A total of 150 SLE patients and 40 healthy volunteers were enrolled in this study. A complete clinical, laboratory and neurological evaluation was performed. MRI scans were performed in a 2T scanner (Elscint Prestige? and coronal T1 weighted images were used for manual volumetric measurements. Atrophy was defined as values below 2 standard deviations (SD) from the means of controls. Results: At study entry, the mean right and left hippocampal volumes of patients were significantly smaller than the hippocampal volumes of healthy controls (p<0.001). After the follow-up MRI we observed a significant progression of reduction of right and left hippocampal volume in patients (p<0.0001). At study entry we identified atrophy in 43.9% and at follow up in 66.7% of SLE patients. Hippocampal atrophy was related to disease duration, total corticosteroid dose and past history of CNS manifestations. Progression of atrophy was associated with cumulative corticosteroid dose and number of CNS events. Patients with cognitive impairment had more severe hippocampal atrophy than patients without this manifestation. Conclusion: Disease duration, total corticosteroid dose and greater number of CNS manifestations were associated with hippocampal atrophy in SLE patients. We observed a significant progression of hippocampal atrophy related to total corticosteroid dose and number of CNS events. Further studies are necessary to confirm these findings. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://ard.bmj.com/cgi/content/short/ard.2005.049486v1Test; http://dx.doi.org/10.1136/ard.2005.049486Test |
| DOI: | 10.1136/ard.2005.049486 |
| الإتاحة: | https://doi.org/10.1136/ard.2005.049486Test http://ard.bmj.com/cgi/content/short/ard.2005.049486v1Test |
| حقوق: | Copyright (C) 2006, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.857B7BFB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/ard.2005.049486 |
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