دورية أكاديمية
The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints
| العنوان: | The Genes–Stemness–Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints |
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| المؤلفون: | Stella G. M., Marchio C., Bari E., Ferrarotti I., Bertuccio F. R., Di Gennaro A., Abbott D. M., Putignano P., Campo I., Torre M. L., Corsico A. G. |
| المساهمون: | Stella, G. M., Marchio, C., Bari, E., Ferrarotti, I., Bertuccio, F. R., Di Gennaro, A., Abbott, D. M., Putignano, P., Campo, I., Torre, M. L., Corsico, A. G. |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi del Piemonte Orientale: CINECA IRIS |
| مصطلحات موضوعية: | genetic, malignant pleural mesothelioma, microenvironment, targeted therapies |
| الوصف: | MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of MPM genetic asset and its interconnection with the surrounding hypoxic microenvironment as well as transcript products and microvesicles representing both an insight into the pathogenesis and promising actionable targets. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36834912; info:eu-repo/semantics/altIdentifier/wos/WOS:000938522100001; volume:24; issue:4; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11579/150663Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85149052886 |
| DOI: | 10.3390/ijms24043496 |
| الإتاحة: | https://doi.org/10.3390/ijms24043496Test https://hdl.handle.net/11579/150663Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.85647670 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms24043496 |
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