التفاصيل البيبلوغرافية
| العنوان: |
Heterologous protein production in filamentous fungi |
| المؤلفون: |
Liu, Dujuan, Garrigues, Sandra, de Vries, Ronald P. |
| المساهمون: |
China Scholarship Council |
| المصدر: |
Applied Microbiology and Biotechnology ; volume 107, issue 16, page 5019-5033 ; ISSN 0175-7598 1432-0614 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Applied Microbiology and Biotechnology, General Medicine, Biotechnology |
| الوصف: |
Filamentous fungi are able to produce a wide range of valuable proteins and enzymes for many industrial applications. Recent advances in fungal genomics and experimental technologies are rapidly changing the approaches for the development and use of filamentous fungi as hosts for the production of both homologous and heterologous proteins. In this review, we highlight the benefits and challenges of using filamentous fungi for the production of heterologous proteins. We review various techniques commonly employed to improve the heterologous protein production in filamentous fungi, such as strong and inducible promoters, codon optimization, more efficient signal peptides for secretion, carrier proteins, engineering of glycosylation sites, regulation of the unfolded protein response and endoplasmic reticulum associated protein degradation, optimization of the intracellular transport process, regulation of unconventional protein secretion, and construction of protease-deficient strains. Key points • This review updates the knowledge on heterologous protein production in filamentous fungi. • Several fungal cell factories and potential candidates are discussed. • Insights into improving heterologous gene expression are given. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1007/s00253-023-12660-8 |
| DOI: |
10.1007/s00253-023-12660-8.pdf |
| DOI: |
10.1007/s00253-023-12660-8/fulltext.html |
| الإتاحة: |
https://doi.org/10.1007/s00253-023-12660-8Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.85003503 |
| قاعدة البيانات: |
BASE |
