التفاصيل البيبلوغرافية
| العنوان: |
Table_2_Patient-Reported and Oncological Outcomes of Salvage Therapies for PSMA-Positive Nodal Recurrent Prostate Cancer: Real-Life Experiences and Implications for Future Trial Design.docx |
| المؤلفون: |
Alexander Kretschmer, Johanna Milow, Chukwuka Eze, Alexander Buchner, Minglun Li, Thilo Westhofen, Frederik Fuchs, Paul Rogowski, Christian Trapp, Ute Ganswindt, Mathias Johannes Zacherl, Leonie Beyer, Vera Wenter, Peter Bartenstein, Boris Schlenker, Christian G. Stief, Claus Belka, Nina-Sophie Schmidt-Hegemann |
| سنة النشر: |
2021 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, prostate cancer, PROMS, PSMA - prostate specific membrane antigen, salvage lymph node dissection, salvage radiotherapy |
| الوصف: |
Introduction The role of salvage lymph node dissection (SLND) and radiotherapy (SLNRT) in the management of nodal-only recurrent prostate cancer (PC) remains controversial. In addition, impact on health-related quality of life (HRQOL) has not been adequately evaluated yet. Materials and Methods Analysis was limited to patients that were diagnosed with nodal-only recurrent PC via PSMA-PET/CT. SLND was performed via open approach. For SLNRT, dose regimens were normo- or slightly hypo-fractionated with a simultaneous boost to the PET-positive recurrences. EORTC QLQ-C30 and PR-25 questionnaires were used to assess HRQOL. Continence status was assessed using daily pad usage and the validated ICIQ-SF questionnaire. For multivariable analysis, Cox regression models were used (p<0.05). Results 138 patients (SLND: 71; SLNRT: 67) were included in the retrospective analysis. Median follow-up was 47 months (mo) for SLNRT patients (IQR 40–61), and 33mo for SLND patients (IQR 20–49; p<0.001). In total, 61 patients (91.0%) in the SLNRT cohort and 43 patients (65.2%; p<0.001) in the SLND cohort underwent ADT anytime during the follow-up period. In multivariate Cox regression analysis, SLNRT could be confirmed as an independent predictor for increased PSA progression-free survival (PFS; HR 0.08, 95%CI 0.040 – 0.142, p<0.001). Estimated median metastasis-free survival (MFS) was 70mo for the total cohort without statistically significant differences between both subgroups (p=0.216). There were no significant differences regarding general HRQOL, daily pad usage, and ICIQ-SF scores between the respective cohorts. Conclusions In a large contemporary series of patients with nodal-only recurrent PC based on PSMA-PET/CT staging, we observed significantly increased PSA PFS in patients undergoing SLNRT while no significant differences could be observed in MFS, and functional outcomes including HRQOL. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Table_2_Patient-Reported_and_Oncological_Outcomes_of_Salvage_Therapies_for_PSMA-Positive_Nodal_Recurrent_Prostate_Cancer_Real-Life_Experiences_and_Implications_for_Future_Trial_Design_docx/14814498Test |
| DOI: |
10.3389/fonc.2021.708595.s003 |
| الإتاحة: |
https://doi.org/10.3389/fonc.2021.708595.s003Test
https://figshare.com/articles/dataset/Table_2_Patient-Reported_and_Oncological_Outcomes_of_Salvage_Therapies_for_PSMA-Positive_Nodal_Recurrent_Prostate_Cancer_Real-Life_Experiences_and_Implications_for_Future_Trial_Design_docx/14814498Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.84B49EAA |
| قاعدة البيانات: |
BASE |
