دورية أكاديمية
Urinary Fetuin-A Fragments Predict Progressive eGFR Decline in Two Independent Type 2 Diabetes Cohorts of Different Ethnicities
| العنوان: | Urinary Fetuin-A Fragments Predict Progressive eGFR Decline in Two Independent Type 2 Diabetes Cohorts of Different Ethnicities |
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| المؤلفون: | Chuang, Gwo-Tsann, Kremer, Daan, Huang, Chi-Hsuan, Alkaff, Firas F, Lin, Chih-Hung, Tseng, Tzu-Ling, Laverman, Gozewijn D, Bakker, Stephan J L, Chuang, Lee-Ming |
| المصدر: | Chuang , G-T , Kremer , D , Huang , C-H , Alkaff , F F , Lin , C-H , Tseng , T-L , Laverman , G D , Bakker , S J L & Chuang , L-M 2024 , ' Urinary Fetuin-A Fragments Predict Progressive eGFR Decline in Two Independent Type 2 Diabetes Cohorts of Different Ethnicities ' , American Journal of Nephrology , vol. 55 , no. 1 , pp. 106-114 . https://doi.org/10.1159/000534514Test |
| سنة النشر: | 2024 |
| المجموعة: | University of Groningen research database |
| الوصف: | Introduction: There is a great clinical need for novel markers to predict kidney function decline in patients with type 2 diabetes. We explored the potential of post-translationally modified fetuin-A fragments in urine (uPTM-FetA) as such a marker. Methods: We included patients with type 2 diabetes from two independent, non-overlapping prospective cohort studies. A cut-off for uPTM-FetA, measured via ELISA method, was determined using the Youden index in the primary cohort of patients with type 2 diabetes from Taiwan. Kidney endpoint was defined as an eGFR decline ≥30% from baseline, reaching of an eGFR<15 mL/min/1.73 m2, or a need of renal replacement therapy. Prospective associations were assessed in Cox regression models. All analyses were replicated in a cohort of patients with type 2 diabetes from the Netherlands. Results: In total, 294 patients with type 2 diabetes (age 61±10 years, 55% male, eGFR 88±16 ml/min/1.73m2) were included in the primary cohort. During a follow-up of median 4.6 years, 42 participants (14%) experienced the kidney endpoint. Using the defined cut-off, a high uPTM-FetA was associated with a higher risk of renal function decline (Plog-rank <0.0001). This association was similar in subgroups depending on albuminuria. This association remained, independent of age, sex, baseline eGFR, albuminuria, HbA1c, and other potential confounders (HR: 9.94; 95% CI: 2.96-33.40; P<0.001 in the final model). Analyses in the validation cohort (376 patients with type 2 diabetes, age 64±11 years, 66% male, eGFR 76±24 ml/min/1.73m2) using the same cut-off yielded similar results. Discussion/Conclusion: uPTM-FetA was independently associated with kidney function decline in patients with type 2 diabetes validated in a 2-cohort study. The significant additive predictive power of this biomarker from conventional risk factors suggests its clinical use for renal function progression in patients with type 2 diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/baf55c4a-810e-47d1-9152-a8dbf8a6dae1Test |
| DOI: | 10.1159/000534514 |
| الإتاحة: | https://doi.org/10.1159/000534514Test https://hdl.handle.net/11370/baf55c4a-810e-47d1-9152-a8dbf8a6dae1Test https://research.rug.nl/en/publications/baf55c4a-810e-47d1-9152-a8dbf8a6dae1Test https://pure.rug.nl/ws/files/903424884/Urinary_Fetuin-A_Fragments_Predict_Progressive_Estimated_Glomerular_Filtration_Rate_Decline.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.84198149 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000534514 |
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