التفاصيل البيبلوغرافية
| العنوان: |
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration |
| المؤلفون: |
Nawaz, Allah, Bilal, Muhammad, Fujisaka, Shiho, Kado, Tomonobu, Aslam, Muhammad Rahil, Ahmed, Saeed, Okabe, Keisuke, Igarashi, Yoshiko, Watanabe, Yoshiyuki, Kuwano, Takahide, Tsuneyama, Koichi, Nishimura, Ayumi, Nishida, Yasuhiro, Yamamoto, Seiji, Sasahara, Masakiyo, Imura, Johji, Mori, Hisashi, Matzuk, Martin M., Kudo, Fujimi, Manabe, Ichiro, Uezumi, Akiyoshi, Nakagawa, Takashi, Oishi, Yumiko, Tobe, Kazuyuki |
| بيانات النشر: |
Springer Nature |
| سنة النشر: |
2024 |
| المجموعة: |
Tokushima University Institutional Repository / 徳島大学機関リポジトリ |
| الوصف: |
Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-adipogenic progenitors (FAPs), and macrophages. How macrophages regulate the paracrine secretion of FAPs during the recovery process remains elusive. Herein, we systemically investigated the communication between CD206+ M2-like macrophages and FAPs during the recovery process using a transgenic mouse model. Depletion of CD206+ M2-like macrophages or deletion of CD206+ M2-like macrophages-specific TGF-β1 gene induces myogenesis and muscle regeneration. We show that depletion of CD206+ M2-like macrophages activates FAPs and activated FAPs secrete follistatin, a promyogenic factor, thereby boosting the recovery process. Conversely, deletion of the FAP-specific follistatin gene results in impaired muscle stem cell function, enhanced fibrosis, and delayed muscle regeneration. Mechanistically, CD206+ M2-like macrophages inhibit the secretion of FAP-derived follistatin via TGF-β signaling. Here we show that CD206+ M2-like macrophages constitute a microenvironment for FAPs and may regulate the myogenic potential of muscle stem/satellite cells. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
20411723 |
| العلاقة: |
http://repo.lib.tokushima-u.ac.jp/files/public/11/118935/20240129144935668776/ncomms_13_7058.pdfTest; AA12645905; http://repo.lib.tokushima-u.ac.jp/118935Test |
| الإتاحة: |
http://repo.lib.tokushima-u.ac.jp/118935Test |
| حقوق: |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0Test/. |
| رقم الانضمام: |
edsbas.8354746B |
| قاعدة البيانات: |
BASE |
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