دورية أكاديمية
Optical coherence tomography-based evaluation of in-stent neoatherosclerosis in lesions with more than 50% neointimal cross-sectional area stenosis
| العنوان: | Optical coherence tomography-based evaluation of in-stent neoatherosclerosis in lesions with more than 50% neointimal cross-sectional area stenosis |
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| المساهمون: | Lee SY, Shin DH, Mintz GS, Kim JS, Kim BK, Ko YG, Choi D, Jang Y, Hong MK, Ko, Young Guk, Kim, Byeong Keuk, Kim, Jung Sun, Shin, Dong Ho, Lee, Seung Yul, Jang, Yang Soo, Choi, Dong Hoon, Hong, Myeong Ki |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Aged, 80 and over, Atherosclerosis/pathology, Constriction, Pathologic/pathology, Coronary Stenosis/pathology, Coronary Vessels/pathology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neointima/diagnosis, Neointima/epidemiology, Neointima/pathology, Stents/adverse effects, Time Factors, Tomography, Optical Coherence*/methods, stent, coronary artery disease, optical coherence tomography |
| الوصف: | AIMS: To use optical coherence tomography (OCT) to evaluate the time course, risk factors, and clinical implication of in-stent neoatherosclerosis. METHODS AND RESULTS: The neointimal characteristics of 152 lesions, 128 drug-eluting stents (DESs) and 24 bare metal stents (BMSs), with >50% percent cross-sectional area (CSA) neointimal stenosis were evaluated. Neoatherosclerosis was defined as neointima with presence of lipid or calcification. Neoatherosclerosis was observed in 54 lesions (35.5%, 35 DESs and 19 BMSs). Median time to follow-up was 70.7 months in lesions with neoatherosclerosis (longer than lesions without neoatherosclerosis [13.4 months, p<0.001]): 58.7 months in DES-treated lesions and 129.5 months in BMS-treated lesions (p<0.001). The optimal cut-off time to predict neoatherosclerosis in DES-treated lesions was 30 months with a sensitivity of 91.4% and a specificity of 72.0% (area under curve: 0.839, 95% confidence interval: 0.764-0.898, p<0.001). Independent risk factors for neoatherosclerosis were stent age, use of first-generation DES and hypertension. Patients with neoatherosclerosis (versus without neoatherosclerosis) had a higher rate of target lesion revascularisation (92.6% vs. 77.6%, respectively, p=0.018) and stent thrombosis (14.8% vs. 0%, respectively, p<0.001). CONCLUSIONS: Neoatherosclerosis occurred in one-third of stented lesions with >50% percent CSA stenosis of neointima. Late-phase development of neoatherosclerosis might be associated with clinical deterioration of stented lesions. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1774-024X 1969-6213 24384291 |
| العلاقة: | EUROINTERVENTION; J00800; OAK-2013-02512; https://ir.ymlib.yonsei.ac.kr/handle/22282913/88628Test; http://www.pcronline.com/eurointervention/67th_issue/158Test/; T201304368; EUROINTERVENTION, Vol.9(8) : 945-951, 2013 |
| DOI: | 10.4244/EIJV9I8A158 |
| الإتاحة: | https://doi.org/10.4244/EIJV9I8A158Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/88628Test http://www.pcronline.com/eurointervention/67th_issue/158Test/ |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ ; not free |
| رقم الانضمام: | edsbas.82DED57 |
| قاعدة البيانات: | BASE |
| تدمد: | 1774024X 19696213 24384291 |
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| DOI: | 10.4244/EIJV9I8A158 |