دورية أكاديمية
Prediagnostic adult body mass index change and esophageal adenocarcinoma survival
| العنوان: | Prediagnostic adult body mass index change and esophageal adenocarcinoma survival |
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| المؤلفون: | Loehrer, E. (Elizabeth), Giovannucci, E.L. (Edward L.), Betensky, R.A. (Rebecca A.), Shafer, A. (Andrea), Christiani, D.C. (David C.) |
| المصدر: | Cancer Medicine |
| سنة النشر: | 2020 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | adenocarcinoma, body mass index, body weight changes, esophageal neoplasms, survival analysis |
| الوصف: | Background: We examined whether body mass index (BMI) changes in adulthood, prior to disease onset, are associated with overall survival among esophageal adenocarcinoma patients. Methods: We included 285 histologically confirmed patients with a complete baseline BMI questionnaire. Using extended Cox regression models, we obtained adjusted hazard ratios (HRs) for the associations between overall survival and BMI at diagnosis, BMI 6 months before diagnosis, self-reported average adult BMI, and ΔBMI (BMI 6 months before diagnosis minus average adult BMI), categorized into tertiles <0 kg/m2 (BMI loss), ≥0 and <1.25 kg/m2 (stable BMI), and ≥1.25 kg/m2 (BMI gain). We also assessed interaction between ΔBMI and average adult BMI (≥ kg/m2 versus <27.5 kg/m2) with overall survival. Results: Body mass index at diagnosis >25 and <35 kg/m2 was associated with better overall survival. Compared to patients with stable BMI in adulthood, patients who gained BMI throughout adulthood had 1.68 times the all-cause hazard of death (95% CI: 1.17-2.43; P <.01), independent of diagnosis BMI and percent weight loss 6 months before diagnosis. Compared to patients with average adult BMI < 27.5 who maintained stable adult BMI, patients with average adult BMI ≥ 27.5 kg/m2 who gained BMI had the worst survival (HR = 3.05; 95% CI 1.62-5.72; P <.01). Conclusion: Body mass index gain in adulthood is associated with poor overall survival, and maintaining a normal body weight throughout adulthood is associated with the best overall survival among esophageal adenocarcinoma patients, independent of BMI at diagnosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/125803Test; urn:hdl:1765/125803 |
| DOI: | 10.1002/cam4.3015 |
| الإتاحة: | https://doi.org/10.1002/cam4.3015Test http://repub.eur.nl/pub/125803Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.826F0855 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cam4.3015 |
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