دورية أكاديمية
Risk factors for progression of paroxysmal to persistent atrial fibrillation following successful PV isolation
| العنوان: | Risk factors for progression of paroxysmal to persistent atrial fibrillation following successful PV isolation |
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| المؤلفون: | Mohanty, S, Trivedi, C, Della Rocca, D.G, Gianni, C, Salwan, A, Macdonald, B, Mayedo, A, Bassiouny, M, Gallinghouse, G.J, Burkhardt, J.D, Horton, R, Al-Ahmad, A, Di Biase, L.D, Natale, A |
| المصدر: | European Heart Journal ; volume 41, issue Supplement_2 ; ISSN 0195-668X 1522-9645 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background Progression from paroxysmal (PAF) to persistent atrial fibrillation (PerAF) following effective PV isolation (PVI) has important clinical implications, as it is relevant for subsequent management of the arrhythmia. Objective We evaluated risk factors responsible for progression of PAF to PerAF following successful PVI. Methods Consecutive AF patients that received their first catheter ablation as well as the first redo at our center were identified (n=1352). Patients were included in group 1 if the diagnosis was PAF at both first and redo procedure (PAF to PAF) and group 2 if PAF at index progressed to PerAF at redo. All patients received PVI plus isolation of LA posterior wall and SVC at the first procedure. Results A total of 822 patients remained as PAF at redo, whereas 530 (39%) progressed from PAF to PerAF. Clinical characteristics of the study population are presented in table 1. In multivariate analysis, BMI (OR 1.02, 1.01–1.04, p=0.04), hypertension (1.4, 1.08–1.8, p=0.01), heart failure (1.67, 1.03–2.69, p=0.03), LA size (2.75, 2.29–3.31, p<0.001) were independent predictors of progression of PAF to PerAF. Data on serum-transthyretin level was available for 37 and 48 patients in group 1 and 2 respectively. It was <18 mg/dL (normal) in 33 (68.7%) patients in group 2 vs 6 (16.2%) in group 1 (p<0.001). Conclusion In our patients, after successful PVI, progression of PAF to PerAF was mediated by independent risk factors such as high BMI, heart failure, hypertension, larger LA size and lower LVEF. Funding Acknowledgement Type of funding source: None |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ehjci/ehaa946.0592 |
| الإتاحة: | https://doi.org/10.1093/ehjci/ehaa946.0592Test http://academic.oup.com/eurheartj/article-pdf/41/Supplement_2/ehaa946.0592/34518193/ehaa946.0592.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.825B87E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjci/ehaa946.0592 |
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