دورية أكاديمية
The impact of the Antenatal Late Preterm Steroids trial on the administration of antenatal corticosteroids
| العنوان: | The impact of the Antenatal Late Preterm Steroids trial on the administration of antenatal corticosteroids |
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| المؤلفون: | Kearsey, Elise O.R., Been, Jasper V., Souter, Vivienne L., Stock, Sarah J. |
| المصدر: | Kearsey , E O R , Been , J V , Souter , V L & Stock , S J 2022 , ' The impact of the Antenatal Late Preterm Steroids trial on the administration of antenatal corticosteroids ' , American Journal of Obstetrics and Gynecology , vol. 227 , no. 2 , pp. 280.e1-280.e15 . https://doi.org/10.1016/j.ajog.2022.03.037Test |
| سنة النشر: | 2022 |
| الوصف: | Background: In 2016 the Antenatal Late Preterm Steroids study was published, demonstrating that antenatal corticosteroid therapy given to women at risk of late preterm delivery reduces respiratory morbidity in infants. However, the administration of antenatal corticosteroid therapy in late-preterm infants remains controversial. Late-preterm infants do not suffer from the same rates of morbidity as early-preterm infants, and the short-term benefits of antenatal corticosteroid therapy are less pronounced; consequently, the risk of possible harm is more difficult to balance. Objective: This study aimed to evaluate the association between the publication of the Antenatal Late Preterm Steroids study or the subsequent changes in guidelines and the rates of antenatal corticosteroid therapy administration in late-preterm infants in the United States. Study Design: Data analyzed were publicly available US birth certificate data from January 1, 2016 to December 31, 2018. An interrupted time series design was used to analyze the association between publication of the Antenatal Late Preterm Steroids study and changes in monthly rates of antenatal corticosteroid administration in late preterm gestation (34+0 to 36+6 weeks). Births at 28+0 to 31+6 weeks’ gestation were used as a control. Antenatal corticosteroid therapy administration in women with births at 32+0 to 34+6 weeks was explored to analyze whether the intervention influenced antenatal corticosteroid therapy administration in women in the subgroup approaching 34 weeks’ gestation. Antenatal corticosteroid therapy administration in women with term births (>37 weeks’ gestation) was analyzed to explore if the intervention influenced the number of term babies exposed to antenatal corticosteroid therapy. Our regression model allowed analysis of both step and slope changes. February 2016 was chosen as the intervention period. Results: Our sample size was 18,031,950 total births. Of these, 1,056,047 were births at 34+0 to 36+6 weeks’ gestation, 123,788 at 28+0 to 31+6 ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.eur.nl/en/publications/0fac8c72-3995-42fb-8aac-9d714fe8f96aTest |
| DOI: | 10.1016/j.ajog.2022.03.037 |
| الإتاحة: | https://doi.org/10.1016/j.ajog.2022.03.037Test https://pure.eur.nl/en/publications/0fac8c72-3995-42fb-8aac-9d714fe8f96aTest https://pure.eur.nl/ws/files/60567346/1_s2.0_S0002937822002083_main.pdfTest http://www.scopus.com/inward/record.url?scp=85130042328&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.823C0E60 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ajog.2022.03.037 |
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