دورية أكاديمية
C-30 analogues of betulinic acid as potent cytotoxic agents: design, synthesis, biological evaluation and in-silico studies
| العنوان: | C-30 analogues of betulinic acid as potent cytotoxic agents: design, synthesis, biological evaluation and in-silico studies |
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| المؤلفون: | Santosh K. Rath, Rakesh K. Nagar, Sanjib Das, Govind Yadav, Debaraj Mukherjee, Buddh Singh, Samar Singh, Payare L. Sangwan |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Betulinic acid, cytotoxicity, G1 phase, apoptosis, in silico studies |
| الوصف: | In an endeavour to improve the anti-cancer activity of betulinic acid (BA), a series of C-30 derivatives were envisaged and synthesized with a novel synthetic approach. All the derivatives were evaluated for cytotoxic activity by MTT assay against six different human cancer cell lines: prostate (PC3), lung (A549), human hepatocellular carcinoma (HepG2), human leukemia (Molt-4), pancreatic (Panc-1) and breast (MCF-7). The data revealed that compound 16 was observed most promising cytotoxic agent with IC 50 values of 7.43 μM, 9.1 μM, and 9.64 μM against A549, MCF-7, and PC3 cancer cell lines respectively. A further mechanistic study confirmed compound 16 showed significant cell death by arresting the cell cycle in the G1 phase and inducing apoptosis in A549 cells. Communicated by Ramaswamy H. Sarma |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/C-30_analogues_of_betulinic_acid_as_potent_cytotoxic_agents_design_synthesis_biological_evaluation_and_i_in-silico_i_studies/25321314Test |
| DOI: | 10.6084/m9.figshare.25321314.v1 |
| الإتاحة: | https://doi.org/10.6084/m9.figshare.25321314.v1Test https://figshare.com/articles/journal_contribution/C-30_analogues_of_betulinic_acid_as_potent_cytotoxic_agents_design_synthesis_biological_evaluation_and_i_in-silico_i_studies/25321314Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.822583EA |
| قاعدة البيانات: | BASE |
| DOI: | 10.6084/m9.figshare.25321314.v1 |
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