دورية أكاديمية
A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations
| العنوان: | A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations |
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| المؤلفون: | Jennifer L Fogel, Daniel L Lakeland, In Kyoung Mah, Francesca V Mariani |
| المصدر: | eLife, Vol 6 (2017) |
| بيانات النشر: | eLife Sciences Publications Ltd |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | skeletal patterning, rib development, Hedgehog, programmed cell death, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | For decades, the mechanism of skeletal patterning along a proximal-distal axis has been an area of intense inquiry. Here, we examine the development of the ribs, simple structures that in most terrestrial vertebrates consist of two skeletal elements—a proximal bone and a distal cartilage portion. While the ribs have been shown to arise from the somites, little is known about how the two segments are specified. During our examination of genetically modified mice, we discovered a series of progressively worsening phenotypes that could not be easily explained. Here, we combine genetic analysis of rib development with agent-based simulations to conclude that proximal-distal patterning and outgrowth could occur based on simple rules. In our model, specification occurs during somite stages due to varying Hedgehog protein levels, while later expansion refines the pattern. This framework is broadly applicable for understanding the mechanisms of skeletal patterning along a proximal-distal axis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | https://elifesciences.org/articles/29144Test; https://doaj.org/toc/2050-084XTest; e29144; https://doaj.org/article/ea693fa510df43adbdd0b9c591c8ff15Test |
| DOI: | 10.7554/eLife.29144 |
| الإتاحة: | https://doi.org/10.7554/eLife.29144Test https://doaj.org/article/ea693fa510df43adbdd0b9c591c8ff15Test |
| رقم الانضمام: | edsbas.821DCCBD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.29144 |