دورية أكاديمية
Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women.
| العنوان: | Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women. |
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| المؤلفون: | Capel, Frédéric, Viguerie, Nathalie, Vega, Nathalie, Dejean, Sébastien, Arner, Peter, Klimcáková, Eva, Martinez, J Alfredo, Saris, Wim, H. M., Holst, Claus, Taylor, Moira, A., Oppert, Jean-Michel, Sørensen, Thorkild, I. A., Clément, Karine, Vidal, Hubert, Langin, Dominique |
| المساهمون: | Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Endocrinologie, maladies métaboliques et nutrition CHU Toulouse, Pôle Cardiovasculaire et Métabolique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), IFR 31 Louis Bugnard (IFR 31), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service Anatomie et cytologie pathologiques CHU Toulouse, Pôle Biologie CHU Toulouse, Franco-Czech Laboratory for Clinical Research on Obesity, Institut National de la Santé et de la Recherche Médicale (INSERM)-Univerzita Karlova Praha, Česká republika = Charles University Prague, Czech Republic (UK), Faculté de Médecine Lyon-Sud, FACULTE DE LYON, Centre de Recherche en Nutrition Humaine, Hospices Civils de Lyon (HCL), Régulations métaboliques, nutrition et diabètes - UM55 (RMND UM55), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Midicine Karolinska Institute, Karolinska University Hospital Huddinge, Department of Sports Medicine of Charles University, 1. lékařská fakulta, Univerzita Karlova Praha, Česká republika = First Faculty of Medicine, Charles University Prague, Czech Republic (1. LF UK / 1st Faculty of Medicine), Univerzita Karlova Praha, Česká republika = Charles University Prague, Czech Republic (UK)-Univerzita Karlova Praha, Česká republika = Charles University Prague, Czech Republic (UK), Department of Physiology and nutrition University of Navarra, Universidad de Navarra Pamplona (UNAV), Department of Human Biology Nutrition and Toxicology Research Institute, Maastricht University Maastricht, The Netherlands Institute of Preventive Medicine, Institute of Preventive Medicine, School of Biomedical Sciences Queen's Medical Center, University of Nottingham, UK (UON), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| المصدر: | ISSN: 0021-972X. |
| بيانات النشر: | HAL CCSD Endocrine Society |
| سنة النشر: | 2008 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | Adaptor Proteins, Signal Transducing, Adipose Tissue, Adult, Body Composition, Body Mass Index, Reducing, Energy Intake, Energy Metabolism, Fatty Acid-Binding Proteins, Genetic Variation, Humans, Obesity, Oligonucleotide Array Sequence Analysis, RNA, Glucocorticoid, Genetic, Weight Loss, Diet, Female, Microfilament Proteins, Mitochondrial Proteins, Receptors, Sirtuins, Transcription, MESH: Adaptor Proteins, MESH: Adipose Tissue, MESH: Sirtuins, MESH: Transcription, MESH: Adult |
| الوصف: | International audience ; CONTEXT: Hypoenergetic diets are used to reduce body fat mass and metabolic risk factors in obese subjects. The molecular changes in adipose tissue associated with weight loss and specifically related to the dietary composition are poorly understood. OBJECTIVE: We investigated adipose tissue gene expression from human obese women according to energy deficit and the fat and carbohydrate content of the diet. DESIGN AND SETTING: Obese subjects recruited among eight European clinical centers were followed up 10 wk of either a low-fat (high carbohydrate) or a moderate-fat (low carbohydrate) hypoenergetic diet. SUBJECTS: Two sets of 47 women in each dietary arm were selected among 648 subjects matched for anthropometric and biological parameters. MAIN OUTCOME MEASURE: We measured adipose tissue gene expression changes in one set using a candidate gene approach. The other set was used to survey 24,469 transcripts using DNA microarrays. Results were analyzed using dedicated statistical methods. Diet-sensitive regulations were confirmed on the other set of subjects. RESULTS: The two diets induced similar weight loss and similar changes for most of the biological variables except for components of the blood lipid profile. One thousand genes were regulated by energy restriction. We validated an effect of the fat to carbohydrate ratio for five genes (FABP4, NR3C1, SIRT3, FNTA, and GABARAPL2) with increased expression during the moderate-fat diet. CONCLUSIONS: Energy restriction had a more pronounced impact on variations in human adipose tissue gene expression than macronutrient composition. The macronutrient-sensitive regulation of a subset of genes may influence adipose tissue function and metabolic response. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/18782868; hal-00355310; https://hal.science/hal-00355310Test; PRODINRA: 250036; PUBMED: 18782868 |
| DOI: | 10.1210/jc.2008-0814 |
| الإتاحة: | https://doi.org/10.1210/jc.2008-0814Test https://hal.science/hal-00355310Test |
| رقم الانضمام: | edsbas.8167EE57 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/jc.2008-0814 |
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