دورية أكاديمية
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
| العنوان: | Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude |
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| المؤلفون: | Kadalayil, Latha, Alam, Md Zahangir, White, Cory Haley, Ghantous, Akram, Walton, Esther, Gruzieva, Olena, Merid, Simon Kebede, Kumar, Ashish, Roy, Ritu P., Solomon, Olivia, Huen, Karen, Eskenazi, Brenda, Rzehak, Peter, Grote, Veit, Langhendries, Jean Paul, Verduci, Elvira, Ferre, Natalia, Gruszfeld, Darek, Gao, Lu, Guan, Weihua, Zeng, Xuehuo, Schisterman, Enrique F., Dou, John F., Bakulski, Kelly M., Feinberg, Jason I., Soomro, Munawar Hussain, Pesce, Giancarlo, Baiz, Nour, Isaevska, Elena, Plusquin, Michelle, Vafeiadi, Marina, Roumeliotaki, Theano, Langie, Sabine A.S., Standaert, Arnout, Allard, Catherine, Perron, Patrice, Bouchard, Luigi, van Meel, Evelien R., Felix, Janine F., Jaddoe, Vincent W.V., Yousefi, Paul D., Ramlau-Hansen, Cecilia H., Relton, Caroline L., Tobi, Elmar W., Starling, Anne P., Yang, Ivana V., Llambrich, Maria, Santorelli, Gillian, Lepeule, Johanna, Salas, Lucas A., Holloway, J. W. |
| المصدر: | Kadalayil , L , Alam , M Z , White , C H , Ghantous , A , Walton , E , Gruzieva , O , Merid , S K , Kumar , A , Roy , R P , Solomon , O , Huen , K , Eskenazi , B , Rzehak , P , Grote , V , Langhendries , J P , Verduci , E , Ferre , N , Gruszfeld , D , Gao , L , Guan , W , Zeng , X , Schisterman , E F , Dou , J F , .... |
| سنة النشر: | 2023 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | Birth season, Differentially methylated regions (DMR), DNA methylation, Latitude, Meta-analysis, PACE |
| الوصف: | BACKGROUND: Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear. METHODS: We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N?=?9358) and in children aged 1-11 years (12 cohorts, N?=?3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points. RESULTS: We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values? |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://cris.maastrichtuniversity.nl/en/publications/07cd0ed3-212b-4be2-8688-6d1bca0a2070Test |
| DOI: | 10.1186/s13148-023-01542-5 |
| الإتاحة: | https://doi.org/10.1186/s13148-023-01542-5Test https://cris.maastrichtuniversity.nl/en/publications/07cd0ed3-212b-4be2-8688-6d1bca0a2070Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.815C2549 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13148-023-01542-5 |
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