التفاصيل البيبلوغرافية
| العنوان: |
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool |
| المؤلفون: |
Permanyer, Marc, Bošnjak, Berislav, Glage, Silke, Friedrichsen, Michaela, Floess, Stefan, Huehn, Jochen, Patzer, Gwendolyn E., Odak, Ivan, Eckert, Nadine, Zargari, Razieh, Ospina-Quintero, Laura, Georgiev, Hristo, Förster, Reinhold |
| المصدر: |
http://lobid.org/resources/99370675071606441Test#!, 18(2):398-414. |
| سنة النشر: |
2021 |
| المجموعة: |
Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: |
Forkhead Transcription Factors/metabolism [MeSH], Female [MeSH], Mutation [MeSH], Mice, Inbred C57BL [MeSH], Colitis/pathology [MeSH], Forkhead Transcription Factors/genetics [MeSH], T-Lymphocytes, Regulatory/immunology [MeSH], Colitis/immunology [MeSH], Treg heterogeneity, Animals [MeSH], Immunosuppression Therapy [MeSH], Interleukin-2/metabolism [MeSH], Mice [MeSH], Article, Colitis/metabolism [MeSH], Male [MeSH], Interleukin-2 Receptor alpha Subunit/metabolism [MeSH], Signal Transduction [MeSH], scRNA sequencing, IL-2R signaling, Homeostasis [MeSH], Regulatory T cells, Interleukin-2 Receptor alpha Subunit/genetics [MeSH] |
| الوصف: |
Signaling via interleukin-2 receptor (IL-2R) is a requisite for regulatory T (Treg) cell identity and function. However, it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis, lineage stability and function in both resting and inflammatory conditions. Here, we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25, the α-chain of IL-2R, which resulted in diminished receptor expression and reduced IL-2R signaling. Under noninflammatory conditions, Cd25 |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://repository.publisso.de/resource/frl:6442848Test; https://doi.org/10.1038/s41423-020-00599-zTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027001Test/ |
| DOI: |
10.1038/s41423-020-00599-z |
| الإتاحة: |
https://doi.org/10.1038/s41423-020-00599-zTest
https://repository.publisso.de/resource/frl:6442848Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027001Test/ |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.80EC9724 |
| قاعدة البيانات: |
BASE |
