دورية أكاديمية
Evaluation of oxidative stress and erythrocyte properties in children with Henoch-Shoenlein purpura
| العنوان: | Evaluation of oxidative stress and erythrocyte properties in children with Henoch-Shoenlein purpura |
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| المؤلفون: | Küçükatay, Vural, Parlaz, N., Erken, Gülten, Bor-Kucukatay, M., Gürses, Dolunay |
| بيانات النشر: | Kowsar Medical Publishing Company |
| سنة النشر: | 2014 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Erythrocyte deformability, anaphylactoid purpura, article, blood level, chemical parameters, child, clinical article, controlled study, disease course, erythrocyte aggregation, female, gastrointestinal disease, hematological parameters, human, human cell, human tissue, kidney disease, male, malondialdehyde blood level, onset age, oxidative stress, preschool child, Henoch-Schönlein purpura, Malondialdehyde, remission, school child, shear stress, total antioxidant status, malonaldehyde, prednisolone |
| الوصف: | Objective: Pathogenesis of Henoch-Schönlein purpura (HSP) is not clearly defined. The present study was conducted to investigate the alterations in erythrocyte deformability and oxidative stress in HSP and to examine the possible relationship between erythrocyte deformability and organ involvement in this disease. Methods: Plasma malondialdehyde (MDA) levels, total antioxidant status (TAS), erythrocyte deformability and aggregation were measured in 21 children with HSP at the disease onset and during the remission period in comparison with healthy subjects. Findings: HSP patients at the active stage had significantly higher MDA and lower TAS levels (P0.05). Erythrocyte deformability was decreased at the active-stage and increased again at the remission period of HSP (P0.05). Erythrocyte deformability was significantly decreased at four different shear stresses in patients with gastrointestinal system or renal involvement; and decreased at six different shear stresses in patients with gastrointestinal system, and renal involvement compared to the patients without organ involvement (P0.05). No significant difference was observed in aggregation parameters (P>0.05). Conclusion: The present findings emphasize the association between impaired erythrocyte deformability and organ involvement in HSP. © 2014 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-335778-3 0-00-335778-3 |
| تدمد: | 2008-2142 |
| العلاقة: | Iranian Journal of Pediatrics; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/7567Test; 24; 166; 172; 2-s2.0-84898481155; WOS:000335778300008 |
| الإتاحة: | https://hdl.handle.net/11499/7567Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.80AB70C1 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780003357783 0003357783 |
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| تدمد: | 20082142 |