دورية أكاديمية
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
| العنوان: | Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
|---|---|
| المؤلفون: | Romitti, Mirian, Tourneur, Adrien, De Faria Da Fonseca, Barbara, Doumont, Gilles, Gillotay, Pierre, Liao, Xiao Hui, Eski, Sema Elif, Van Simaeys, Gaëtan, Chomette, Laura, Lasolle, Hélène, Monestier, Olivier, Figini Kasprzyk, Dominika, Detours, Vincent, Singh, Sumeet Pal, Goldman, Serge, Refetoff, Samuel, Costagliola, Sabine |
| المصدر: | Nature communications, 13 (1 |
| سنة النشر: | 2022 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles |
| الوصف: | The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of concept for future therapeutic development. ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 2 full-text file(s): application/pdf | application/pdf |
| اللغة: | English |
| العلاقة: | uri/info:doi/10.1038/s41467-022-34776-7; uri/info:pii/34776; uri/info:pmid/36396935; uri/info:scp/85142142663; https://dipot.ulb.ac.be/dspace/bitstream/2013/352747/5/2021-12-01-470729v1-full.pdfTest; https://dipot.ulb.ac.be/dspace/bitstream/2013/352747/1/doi_336391.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/352747Test |
| الإتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/352747Test https://dipot.ulb.ac.be/dspace/bitstream/2013/352747/5/2021-12-01-470729v1-full.pdfTest |
| رقم الانضمام: | edsbas.8093794D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |