التفاصيل البيبلوغرافية
| العنوان: |
Role of Mitochondria in Nonalcoholic Fatty Liver Disease |
| المؤلفون: |
Fatiha Nassir, Jamal Ibdah |
| المصدر: |
International Journal of Molecular Sciences; Volume 15; Issue 5; Pages: 8713-8742 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2014 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
NAFLD, NASH, mitochondria, liver, steatosis, fatty acid oxidation, PGC-1α, sirtuin-1 (SIRT1), sirtuin-3 (SIRT3) |
| جغرافية الموضوع: |
agris |
| الوصف: |
Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Significant insight has been gained into our understanding of the pathogenesis of NALFD; however the key metabolic aberrations underlying lipid accumulation in hepatocytes and the progression of NAFLD remain to be elucidated. Accumulating and emerging evidence indicate that hepatic mitochondria play a critical role in the development and pathogenesis of steatosis and NAFLD. Here, we review studies that document a link between the pathogenesis of NAFLD and hepatic mitochondrial dysfunction with particular focus on new insights into the role of impaired fatty acid oxidation, the transcription factor peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and sirtuins in development and progression of NAFLD. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms15058713Test |
| DOI: |
10.3390/ijms15058713 |
| الإتاحة: |
https://doi.org/10.3390/ijms15058713Test |
| حقوق: |
https://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: |
edsbas.8076845D |
| قاعدة البيانات: |
BASE |
