دورية أكاديمية
Impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention:an analysis from the e-Ultimaster registry
| العنوان: | Impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention:an analysis from the e-Ultimaster registry |
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| المؤلفون: | Kobo, Ofer, Saada, Majdi, Von Birgelen, Clemens, Tonino, Pim A.L., Íñiguez-Romo, Andres, Fröbert, Ole, Halabi, Majdi, Oemrawsingh, Rohit M., Polad, Jawed, Ijsselmuiden, Alexander J.J., Roffi, Marco, Aminian, Adel, Mamas, Mamas A., Roguin, Ariel |
| المصدر: | Kobo , O , Saada , M , Von Birgelen , C , Tonino , P A L , Íñiguez-Romo , A , Fröbert , O , Halabi , M , Oemrawsingh , R M , Polad , J , Ijsselmuiden , A J J , Roffi , M , Aminian , A , Mamas , M A & Roguin , A 2023 , ' Impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention : an analysis from the e-Ultimaster registry ' , European Heart Journal - Quality of Care and Clinical Outcomes , vol. 9 .... |
| سنة النشر: | 2023 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | clinical trial, human, percutaneous coronary intervention, Poly-vascular disease, vascular disease |
| الوصف: | Background: Multisite artery disease is considered a 'malignant' type of atherosclerotic disease associated with an increased cardiovascular risk, but the impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention (PCI) is unknown. Methods: Patients enrolled in the large, prospective e-Ultimaster study were grouped into (1) those without known prior vascular disease, (2) those with known single-territory vascular disease, and (3) those with known two to three territories (i.e coronary, cerebrovascular, or peripheral) vascular disease (multisite artery disease). The primary outcome was coronary target lesion failure (TLF), defined as the composite of cardiac death, target vessel-related myocardial infarction, and clinically driven target lesion revascularization at 1-year. Inverse propensity score weighted (IPSW) analysis was performed to address differences in baseline patient and lesion characteristics. Results: Of the 37 198 patients included in the study, 62.3% had no prior known vascular disease, 32.6% had single-territory vascular disease, and 5.1% had multisite artery disease. Patients with known vascular disease were older and were more likely to be men and to have more co-morbidities. After IPSW, the TLF rate incrementally increased with the number of diseased vascular beds (3.16%, 4.44%, and 6.42% for no, single, and multisite artery disease, respectively, P < 0.01 for all comparisons). This was also true for all-cause death (2.22%, 3.28%, and 5.29%, P < 0.01 for all comparisons) and cardiac mortality (1.26%, 1.91%, and 3.62%, P ≤ 0.01 for all comparisons). Conclusions: Patients with previously known vascular disease experienced an increased risk of adverse cardiovascular events and mortality post-PCI. This risk is highest among patients with multisite artery disease.: Trial Registration: URL: https://www.clinicaltrials.govTest. Unique identifier: NCT02188355. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/en/publications/19674e07-1e3f-4c2f-a425-bf3f001a53b8Test |
| DOI: | 10.1093/ehjqcco/qcac043 |
| الإتاحة: | https://doi.org/10.1093/ehjqcco/qcac043Test https://pure.au.dk/portal/en/publications/19674e07-1e3f-4c2f-a425-bf3f001a53b8Test http://www.scopus.com/inward/record.url?scp=85163849943&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.806B2DB0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjqcco/qcac043 |
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