دورية أكاديمية
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis
| العنوان: | A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis |
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| المؤلفون: | Zhang, Lin, Orban, Martin, Lorenz, Michael, Barocke, Verena, Braun, Daniel, Urtz, Nicole, Schulz, Christian, Von Brühl, Marie-Luise, Tirniceriu, Anca, Gaertner, Florian, Proia, Richard L., Graf, Thomas, Bolz, Steffen-Sebastian, Montañez, Eloi, Prinz, Marco, Müller, Alexandra, Von Baumgarten, Louisa, Billich, Andreas, Sixt, Michael, Fässler, Reinhard, Von Andrian, Ulrich H., Junt, Tobias, Massberg, Steffen |
| المصدر: | Articles publicats en revistes (Ciències Fisiològiques) |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2012 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Metabolisme, Fisiologia, Transducció de senyal cel·lular, Trombosi, Metabolism, Physiology, Cellular signal transduction, Thrombosis |
| الوصف: | Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood. The mechanisms that control platelet generation remain incompletely understood. Using conditional mutants and intravital multiphoton microscopy, we show here that the lipid mediator sphingosine 1-phosphate (S1P) serves as a critical directional cue guiding the elongation of megakaryocytic PP extensions from the interstitium into BM sinusoids and triggering the subsequent shedding of PPs into the blood. Correspondingly, mice lacking the S1P receptor S1pr1 develop severe thrombocytopenia caused by both formation of aberrant extravascular PPs and defective intravascular PP shedding. In contrast, activation of S1pr1 signaling leads to the prompt release of new platelets into the circulating blood. Collectively, our findings uncover a novel function of the S1P-S1pr1 axis as master regulator of efficient thrombopoiesis and might raise new therapeutic options for patients with thrombocytopenia. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 17 p.; application/pdf |
| اللغة: | English |
| تدمد: | 0022-1007 |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.1084/jem.20121090Test; Journal of Experimental Medicine, 2012, vol. 209, num. 12, p. 2165-2181; https://doi.org/10.1084/jem.20121090Test; http://hdl.handle.net/2445/162035Test; 699842 |
| الإتاحة: | https://doi.org/10.1084/jem.20121090Test http://hdl.handle.net/2445/162035Test |
| حقوق: | (c) Rockefeller University Press, 2012 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.805D4EA0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00221007 |
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