دورية أكاديمية
Increasing prevalence and local transmission of non-B HIV-1 subtypes in the French Antilles and French Guiana between 1995 and 2018
| العنوان: | Increasing prevalence and local transmission of non-B HIV-1 subtypes in the French Antilles and French Guiana between 1995 and 2018 |
|---|---|
| المؤلفون: | Bello, Gonzalo, Delatorre, Edson, Lacoste, Vincent, Darcissac, Edith, Herrmann-Storck, Cécile, Tressières, Benoit, Cabras, Ornella, Lamaury, Isabelle, Cabié, André, Visseaux, Benoit, Chaix, Marie-Laure, Descamps, Diane, Césaire, Raymond, Nacher, Mathieu, dos Santos, Georges |
| المساهمون: | Instituto Oswaldo Cruz / Oswaldo Cruz Institute Rio de Janeiro (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Universidade Federal do Espirito Santo (UFES), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), CHU Pointe-à-Pitre/Abymes Guadeloupe, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes Guadeloupe -CHU de Fort de France-Centre Hospitalier Andrée Rosemon Cayenne, Guyane Française, Maladies infectieuses et tropicales dans la Caraïbe (MAITC EA 4537), CHU Pointe-à-Pitre/Abymes Guadeloupe -CHU de la Martinique Fort de France -Université des Antilles (UA), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Génomes, biologie cellulaire et thérapeutiques (GenCellDi (U944 / UMR7212)), Collège de France (CdF (institution))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This research was supported by grant 14078 from the ANRS. |
| المصدر: | EISSN: 2057-1577 ; Virus Evolution ; https://hal.science/hal-03690874Test ; Virus Evolution, 2020, 6 (2), pp.veaa081. ⟨10.1093/ve/veaa081⟩ |
| بيانات النشر: | HAL CCSD Oxford University Press |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | HIV-1, non-B subtype, HIV cluster, Phylodynamics, French Guiana, Guadeloupe, Martinique, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.BID]Life Sciences [q-bio]/Biodiversity, anthro-se, geo |
| الوصف: | International audience ; The Caribbean and South American French Overseas Territories (CSAFOT) are the regions most heavily affected by the Human Immunodeficiency Virus type 1 (HIV-1) epidemic in France. Although dominated by HIV-1 subtype B, the detection of non-B subtypes and the great proportion of HIV-positive persons born abroad demonstrated the potential for local spread of non-B subtype strains in CSAFOT. To reconstruct the epidemiologic dynamics of major non-B subtype clusters spreading in CSAFOT, we conducted phylogenetic and evolutionary analyses of 2,523 HIV-1 pol sequences collected from patients living in Martinique, Guadeloupe, and French Guiana from 1995 to 2018. A large variety of HIV-1 non-B subtype strains (eight subtypes, twelve CRFs, and multiple URFs) have been introduced in CSAFOT and their prevalence significantly increases over time in Martinique and Guadeloupe. We identified twelve major transmission networks of non-B subtypes (CRF02_AG and subtypes A3, C, D, and F1) that probably arose in Guadeloupe, Martinique, French Guiana, and mainland France between the late 1970s and the middle 2000s. Phylogeographic analyses support frequent non-B subtype viral transmissions within CSAFOT as well as transatlantic transmission between CSAFOT and mainland France. Domestic transmission networks of non-B subtype variants in CSAFOT comprise both men having sex with men and heterosexual individuals from different age groups. Different HIV-1 non-B subtype variants were sequentially introduced in CSAFOT between the late 1970s and the middle 2000s and are currently spreading through domestic, regional, and/or transatlantic networks of individuals from different age and risk groups. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://hal.science/hal-03690874/file/veaa081.pdfTest; https://hal.science/hal-03690874Test |
| الإتاحة: | https://doi.org/10.1093/ve/veaa081Test https://hal.science/hal-03690874/file/veaa081.pdfTest https://hal.science/hal-03690874Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.8056C002 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |