دورية أكاديمية
The common marmoset genome provides insight into primate biology and evolution
| العنوان: | The common marmoset genome provides insight into primate biology and evolution |
|---|---|
| المؤلفون: | Worley, KC, Warren, WC, Rogers, J, Locke, D, Muzny, DM, Mardis, ER, Weinstock, GM, Tardif, SD, Aagaard, KM, Archidiacono, N, Rayan, NA, Batzer, MA, Beal, K, Brejova, B, Capozzi, O, Capuano, SB, Casola, C, Chandrabose, MM, Cree, A, Dao, MD, de Jong, PJ, del Rosario, RC-H, Delehaunty, KD, Dinh, HH, Eichler, EE, Fitzgerald, S, Flicek, P, Fontenot, CC, Fowler, RG, Fronick, C, Fulton, LA, Fulton, RS, Gabisi, RA, Gerlach, D, Graves, TA, Gunaratne, PH, Hahn, MW, Haig, D, Han, Y, Harris, RA, Herrero, J, Hillier, LW, Hubley, R, Hughes, JF, Hume, J, Jhangiani, SN, Jorde, LB, Joshi, V, Karakor, E, Konkel, MK, Kosiol, C, Kovar, CL, Kriventseva, EV, Lee, SL, Lewis, LR, Liu, Y-S, Lopez, J, Lopez-Otin, C, Lorente-Galdos, B, Mansfield, KG, Marques-Bonet, T, Minx, P, Misceo, D, Moncrieff, JS, Morgan, MB, Nazareth, LV, Newsham, I, Ngoc, BN, Okwuonu, G, Prabhakar, S, Perales, L, Pu, L-L, Puente, XS, Quesada, V, Ranck, MC, Raney, BJ, Raveendran, M, Deiros, DR, Rocchi, M, Rodriguez, D, Ross, C, Ruffier, M, Ruiz, SJ, Sajjadian, S, Santibanez, J, Schrider, DR, Searle, S, Skaletsky, H, Soibam, B, Smit, AFA, Tennakoon, JB, Tomaska, L, Ullmer, B, Vejnar, CE, Ventura, M, Vilella, AJ, Vinar, T, Vogel, J-H, Walker, JA, Wang, Q, Warner, CM, Wildman, DE, Witherspoon, DJ, Wright, RA, Wu, Y, Xiao, W, Xing, J, Zdobnov, EM, Zhu, B, Gibbs, RA, Wilson, RK |
| المصدر: | Nature Genetics , 46 (8) pp. 850-857. (2014) |
| بيانات النشر: | NATURE PUBLISHING GROUP |
| سنة النشر: | 2014 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, MULTILOCUS GENOTYPE DATA, INCREASED OVULATION RATE, SEGMENTAL DUPLICATIONS, GENE, GROWTH, MUTATIONS, VARIANTS, VERTEBRATES, CHIMPANZEE, CHIMERISM, Animal physiology, Genomics, Sequencing |
| الوصف: | We report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/1437020/1/Herrero_ng.3042.pdfTest; https://discovery.ucl.ac.uk/id/eprint/1437020Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/1437020/1/Herrero_ng.3042.pdfTest https://discovery.ucl.ac.uk/id/eprint/1437020Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.7FF4B793 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |