دورية أكاديمية
Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.
| العنوان: | Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage. |
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| المؤلفون: | Kaucka, Marketa, Zikmund, Tomas, Tesarova, Marketa, Gyllborg, Daniel, Hellander, Andreas, Jaros, Josef, Kaiser, Jozef, Petersen, Julian, Szarowska, Bara, Newton, Phillip T., Dyachuk, Vyacheslav, Li, Lei, Qian, Hong, Johansson, Anne-Sofie, Mishina, Yuji, Currie, Joshua D., Tanaka, Elly M., Erickson, Alek, Dudley, A T., Brismar, Hjalmar, Southam, Paul, Coen, Enrico, Chen, Min, Weinstein, Lee S., Hampl, Ales, Arenas, Ernest, Chagin, Andrei S., Fried, Kaj, Adameyko, Igor |
| المصدر: | Journal Articles: Genetics, Cell Biology & Anatomy |
| بيانات النشر: | DigitalCommons@UNMC |
| سنة النشر: | 2017 |
| المجموعة: | University of Nebraska Medical Center Research: DigitalCommons@UNMC |
| مصطلحات موضوعية: | BMP, GSalpha, Wnt/PCP, chondrocranium, developmental biology, facial cartilage growth, mathematical and material modelling, mouse, mouse mutants, scaling and shaping, stem cells, Medical Anatomy, Medical Cell Biology, Medical Genetics |
| الوصف: | Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.unmc.edu/com_gcba_articles/29Test; https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1028&context=com_gcba_articlesTest |
| الإتاحة: | https://digitalcommons.unmc.edu/com_gcba_articles/29Test https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1028&context=com_gcba_articlesTest |
| حقوق: | This work is made available under the Creative Commons CCO public domain dedication. Creative Commons Public Domain Dedication 1.0 |
| رقم الانضمام: | edsbas.7FD71069 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |