دورية أكاديمية
Demystifying BRAF Mutation Status in Colorectal Liver Metastases
| العنوان: | Demystifying BRAF Mutation Status in Colorectal Liver Metastases |
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| المؤلفون: | Margonis, Georgios, Boerner, Thomas, Bachet, Jean-Baptiste, Buettner, Stefan, Moretto, Roberto, Andreatos, Nikolaos, Sartore-Bianchi, Andrea, Wang, Jane, Kamphues, Carsten, Gagniere, Johan, Lonardi, Sara, Løes, Inger, Wagner, Doris, Spallanzani, Andrea, Sasaki, Kazunari, Burkhart, Richard, Pietrantonio, Filippo, Pikoulis, Emmanouil, Pawlik, Timothy, Truant, Stéphanie, Orlandi, Armando, Pikouli, Anastasia, Pella, Nicoletta, Beyer, Katharina, Poultsides, George, Seeliger, Hendrik, Aucejo, Federico, Kornprat, Peter, Kaczirek, Klaus, Lønning, Per, Kreis, Martin, Wolfgang, Christopher, Weiss, Matthew, Cremolini, Chiara, Benoist, Stéphane, D’angelica, Michael |
| المساهمون: | Department of Experimental Psychology, University of Oxford, Oxford, UK, CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre d'Investigation Clinique CHU Clermont-Ferrand (CIC 1405), Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction de la recherche clinique et de l’innovation CHU Clermont-Ferrand (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Veneto Institute of Oncology IOV-IRCCS Padua, Italy, Department of Biology, University of Pennsylvania, University of Pennsylvania, Azienda Ospedaleria Universitaria di Modena = University Hospital of Modena, Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute Milan, Service de chirurgie hepato-pancreato-biliaire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Beaujon AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité) |
| المصدر: | ISSN: 0003-4932. |
| بيانات النشر: | HAL CCSD Lippincott, Williams & Wilkins |
| سنة النشر: | 2023 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Objective: To investigate the clinical implications of BRAF -mutated (mut BRAF ) colorectal liver metastases (CRLMs). Background: The clinical implications of mut BRAF status in CRLMs are largely unknown. Methods: Patients undergoing resection for mut BRAF CRLM were identified from prospectively maintained registries of the collaborating institutions. Overall survival (OS) and recurrence-free survival (RFS) were compared among patients with V600E versus non-V600E mutations, KRAS/BRAF comutation versus mut BRAF alone, microsatellite stability status (Microsatellite Stable (MSS) vs instable (MSI-high)), upfront resectable versus converted tumors, extrahepatic versus liver-limited disease, and intrahepatic recurrence treated with repeat hepatectomy versus nonoperative management. Results: A total of 240 patients harboring BRAF -mutated tumors were included. BRAF V600E mutation was associated with shorter OS (30.6 vs 144 mo, P =0.004), but not RFS compared with non-V600E mutations. KRAS/BRAF comutation did not affect outcomes. MSS tumors were associated with shorter RFS (9.1 vs 26 mo, P <0.001) but not OS (33.5 vs 41 mo, P =0.3) compared with MSI-high tumors, whereas patients with resected converted disease had slightly worse RFS (8 vs 11 mo, P =0.01) and similar OS (30 vs 40 mo, P =0.4) compared with those with upfront resectable disease. Patients with extrahepatic disease had worse OS compared with those with liver-limited disease (8.8 vs 40 mo, P <0.001). Repeat hepatectomy after intrahepatic recurrence was associated with improved OS compared with nonoperative management (41 vs 18.7 mo, P =0.004). All results continued to hold true in the multivariable OS analysis. Conclusions: Although surgery may be futile in patients with BRAF -mutated CRLM and concurrent extrahepatic disease, resection of converted disease resulted in encouraging survival in the absence of extrahepatic spread. Importantly, second hepatectomy in select patients with recurrence was associated with improved ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04545454; https://hal.science/hal-04545454Test |
| DOI: | 10.1097/sla.0000000000005771 |
| الإتاحة: | https://doi.org/10.1097/sla.0000000000005771Test https://hal.science/hal-04545454Test |
| رقم الانضمام: | edsbas.7FD57341 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/sla.0000000000005771 |
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