التفاصيل البيبلوغرافية
| العنوان: |
Estimation of intrachromosomal inbreeding depression on female fertility using runs of homozygosity in Finnish Ayrshire cattle |
| المؤلفون: |
Martikainen, K., Sironen, A., Uimari, P. |
| المساهمون: |
Animal Science Research, Department of Agricultural Sciences |
| بيانات النشر: |
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC |
| سنة النشر: |
2020 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
cattle, fertility, inbreeding, inbreeding depression, runs of homozygosity, FOLLICLE DEVELOPMENT, HOLSTEIN, ASSOCIATION, COANCESTRY, NETRIN-G1, PROMOTES, TRAITS, LENGTH, NGL-1, 412 Animal science, dairy science |
| الوصف: |
Inbreeding increases homozygosity, which in turn increases the frequency of harmful recessive alleles, resulting in inbreeding depression. Inbreeding depression on fertility reduces the profitability of dairy farming by decreasing the lifetime milk production of cows and by increasing insemination and veterinary costs. Continuous homozygous segments, called runs of homozygosity (ROH), are currently considered to provide an effective measure of genomic inbreeding. The aim of this study was to estimate the effect of increased intrachromosomal homozygosity for female fertility in the Finnish Ayrshire population using ROH and haplotype analysis. Genotypes were obtained from 13,712 females with the Illumina BovineLD v.2 BeadChip low-density panel (Illumina Inc., San Diego, CA) and imputed to 50K density. After quality control, 40,554 single nucleotide polymorphisms remained for the analysis. Phenotypic data consisted of records for nonreturn rate, intervals from first to last insemination (IFL), and intervals from calving to first insemination. The raw phenotypic values were preadjusted for systematic effects before statistical analyses. The ROH-based inbreeding coefficients (F-ROH) were used as covariats in the mixed model equation to estimate the association between inbreeding and inbreeding depression on female fertility. First, we estimated the effect of increased chromosomal F-ROH. We detected significant inbreeding depression on IFL. Based on our results, a 10% increase in F-ROH on chromosomes 2, 18, and 22 were associated with IFL of heifers lengthening by 1.6, 0.9, and 0.7 d, respectively. Similarly, a 10% increase in F-ROH on chromosome 15 was associated with IFL of second-parity cows increasing by 2.3 d. Next, we located the regions within the chromosomes showing inbreeding depression. Our analysis revealed regions near the beginning of chromosome 2 and toward the ends of chromosomes 15, 18, and 22 that were associated with inbreeding depression on IFL. Last, we performed a haplotype analysis for the ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
The authors thank the funders of this research, Suomen Naudanjalostussaatio (Hamina, Finland) and the Ministry of Agriculture and Forestry (Helsinki, Finland). We are grateful to NAV (Nordic Cattle Genetic Evaluation, Aarhus, Denmark) and Faba (The Finnish Animal Breeding Association, Hollola, Finland) for providing the genotypes, pedigree data, raw phenotypes, solutions for the fixed effects, and estimates of (co) variance-components used in our study.; Martikainen , K , Sironen , A & Uimari , P 2018 , ' Estimation of intrachromosomal inbreeding depression on female fertility using runs of homozygosity in Finnish Ayrshire cattle ' , Journal of Dairy Science , vol. 101 , no. 12 , pp. 11097-11107 . https://doi.org/10.3168/jds.2018-14805Test; ORCID: /0000-0002-5349-3932/work/51563948; ORCID: /0000-0002-0693-8687/work/129623336; 85054423701; fb2edf91-4f91-48ab-8daa-a36bcdf22b27; http://hdl.handle.net/10138/311118Test; 000450347500045 |
| الإتاحة: |
http://hdl.handle.net/10138/311118Test |
| حقوق: |
openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.7FA24292 |
| قاعدة البيانات: |
BASE |
