دورية أكاديمية
Very low high-density lipoprotein-cholesterol and long-term mortality
| العنوان: | Very low high-density lipoprotein-cholesterol and long-term mortality |
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| المؤلفون: | Dykun, I, Hendricks, S, Babinets, O, Al-Rashid, F, Totzeck, M, Rassaf, T, Mahabadi, A A |
| المصدر: | European Heart Journal ; volume 42, issue Supplement_1 ; ISSN 0195-668X 1522-9645 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background High-density lipoprotein-cholesterol (HDL-C) has anti-atherogenic, anti-inflammatory, anti-oxidative, anti-apoptotic, and vasodilatory properties. While a linear inverse relationship between HDL-C levels and all-cause mortality is established, recent observational studies suggest a U-shaped association between HDL-C and outcome. Purpose We tested the hypothesis that both low and high HDL-C levels associate with long-term mortality. Methods The present analysis is based on the longitudinal ECAD registry of consecutive patients undergoing coronary angiography at the West German Heart and Vascular Center between 2004 and 2019. HDL-C was quantified at hospital admission using standardized enzymatic methods. The incidence of death due to any cause was evaluated during follow-up. Cox regression analysis was used to determine the association of HDL-C with incident mortality, adjusting for age, sex, systolic blood pressure, low-density lipoprotein cholesterol, smoking status, and family history of premature cardiovascular disease. In addition to the analysis on HDL-C as continuous variable, the association of HDL-groups (<10th percentile, 10th-<25th percentile, 25th-<50th percentile, 50th-<75th percentile, 75th-90th percentile, and ≥90thpercentile) with incident mortality was determined using HDL-C <10th percentile as reference. Results Among 17,433 patients, mean age was 65.9±12.6 years and 70.1% were men. Mean HDL-C was 48.7±16.2 mg/dL. During a mean follow-up 3.38±2.10 years, 2,401 patients (13.8%) died. In multivariable analysis, higher HDL-C levels were independently associated with lower all-cause mortality [hazard ratio (95% confidence interval): 0.83 (0.76, 0.91) per 1 standard deviation change in HDL-C, p<0.001]. Associations between HDL-C and mortality were equally present in male [0.83 (0,74, 0.93), p=0.001] and female patients [0.85 (0.73, 1.00), p=0.0496]. Using HDL-C <10thpercentile as reference (<31mg/dl), all other HDL-C groups ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/eurheartj/ehab724.2572 |
| الإتاحة: | https://doi.org/10.1093/eurheartj/ehab724.2572Test https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.2572/41052756/ehab724.2572.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.7F9ABA77 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurheartj/ehab724.2572 |
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