دورية أكاديمية
X-inactivation: quantitative predictions of protein interactions in the Xist network
| العنوان: | X-inactivation: quantitative predictions of protein interactions in the Xist network |
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| المؤلفون: | Agostini F., Cirillo D., Bolognesi B., Tartaglia G. G. |
| المساهمون: | Agostini, F., Cirillo, D., Bolognesi, B., Tartaglia, G. G. |
| بيانات النشر: | Oxford Oxford University Press |
| سنة النشر: | 2013 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Animal, binding, enhancer of Zeste homolog 2 protein, female, heterogeneous-nuclear ribonucleoprotein U, matrix attachment region binding protein, mice, nuclear protein, polycomb repressive complex 2, RNA, long noncoding, RNA-binding protein, repetitive sequences, nucleic acid, serine-arginine splicing factor, YY1 transcription factor, algorithm, X chromosome inactivation |
| الوصف: | The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of epigenetic modifications. Little is known about the molecular machinery regulating initiation and maintenance of chromosomal silencing. Here, we introduce a new version of our algorithm catRAPID to investigate Xist associations with a number of proteins involved in epigenetic regulation, nuclear scaffolding, transcription and splicing processes. Our method correctly identifies binding regions and affinities of protein interactions, providing a powerful theoretical framework for the study of X-chromosome inactivation and other events mediated by ribonucleoprotein associations. © 2012 The Author(s). Published by Oxford University Press. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23093590; info:eu-repo/semantics/altIdentifier/wos/WOS:000312889900031; volume:41; issue:1; firstpage:e31; numberofpages:9; journal:NUCLEIC ACIDS RESEARCH; http://hdl.handle.net/11573/1451739Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84871806618 |
| DOI: | 10.1093/nar/gks968 |
| الإتاحة: | https://doi.org/10.1093/nar/gks968Test http://hdl.handle.net/11573/1451739Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7EFF94C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/nar/gks968 |
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