دورية أكاديمية
Re-wiring regulatory cell networks in immunity by galectin-glycan interactions
| العنوان: | Re-wiring regulatory cell networks in immunity by galectin-glycan interactions |
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| المؤلفون: | Blidner, Ada Gabriela, Mendez Huergo, Santiago Patricio, Cagnoni, Alejandro, Rabinovich, Gabriel Adrián |
| بيانات النشر: | Elsevier Science |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | Galectin1, Glycan, Immunomodulation, Regulatory T Cell, Immunosuppression, https://purl.org/becyt/ford/3.1Test, https://purl.org/becyt/ford/3Test |
| الوصف: | Programs that control immune cell homeostasis are orchestrated through the coordinated action of a number of regulatory cell populations, including regulatory T cells, regulatory B cells, myeloid-derived suppressor cells, alternatively-activated macrophages and tolerogenic dendritic cells. These regulatory cell populations can prevent harmful inflammation following completion of protective responses and thwart the development of autoimmune pathology. However, they also have a detrimental role in cancer by favoring escape from immune surveillance. One of the hallmarks of regulatory cells is their remarkable plasticity as they can be positively or negatively modulated by a plethora of cytokines, growth factors and co-stimulatory signals that tailor their differentiation, stability and survival. Here we focus on the emerging roles of galectins, a family of highly conserved glycan-binding proteins in regulating the fate and function of regulatory immune cell populations, both of lymphoid and myeloid origins. Given the broad distribution of circulating and tissue-specific galectins, understanding the relevance of lectin-glycan interactions in shaping regulatory cell compartments will contribute to the design of novel therapeutic strategies aimed at modulating their function in a broad range of immunological disorders. ; Fil: Blidner, Ada Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina ; Fil: Mendez Huergo, Santiago Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina ; Fil: Cagnoni, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina ; Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0014-5793 1873-3468 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014579315008078Test; http://hdl.handle.net/11336/7740Test; Blidner, Ada Gabriela; Mendez Huergo, Santiago Patricio; Cagnoni, Alejandro; Rabinovich, Gabriel Adrián; Re-wiring regulatory cell networks in immunity by galectin-glycan interactions; Elsevier Science; Febs Letters; 589; 22; 14-11-2015; 3407-3418 |
| الإتاحة: | https://doi.org/10.1016/j.febslet.2015.08.037Test http://hdl.handle.net/11336/7740Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-nd/2.5/arTest/ |
| رقم الانضمام: | edsbas.7EDF3B9E |
| قاعدة البيانات: | BASE |
| تدمد: | 00145793 18733468 |
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