صورة
Image_4_Risk Prediction of Second Primary Malignancies in Primary Early-Stage Ovarian Cancer Survivors: A SEER-Based National Population-Based Cohort Study.tif
| العنوان: | Image_4_Risk Prediction of Second Primary Malignancies in Primary Early-Stage Ovarian Cancer Survivors: A SEER-Based National Population-Based Cohort Study.tif |
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| المؤلفون: | Jiaqin Xu, Chen Huang, Zhenyu Wu, Huilin Xu, Jiong Li, Yuntao Chen, Ce Wang, Jingjing Zhu, Guoyou Qin, Xueying Zheng, Yongfu Yu |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers: Figshare |
| مصطلحات موضوعية: | Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, ovarian cancer, second primary malignancies, competing risk model, nomogram, SEER database |
| الوصف: | Purpose This study aimed to characterize the clinical features of early-stage ovarian cancer (OC) survivors with second primary malignancies (SPMs) and provided a prediction tool for individualized risk of developing SPMs. Methods Data were obtained from the Surveillance, Epidemiology and End Results (SEER) database during 1998–2013. Considering non-SPM death as a competing event, the Fine and Gray model and the corresponding nomogram were used to identify the risk factors for SPMs and predict the SPM probabilities after the initial OC diagnosis. The decision curve analysis (DCA) was performed to evaluate the clinical utility of our proposed model. Results A total of 14,314 qualified patients were enrolled. The diagnosis rate and the cumulative incidence of SPMs were 7.9% and 13.6% [95% confidence interval (CI) = 13.5% to 13.6%], respectively, during the median follow-up of 8.6 years. The multivariable competing risk analysis suggested that older age at initial cancer diagnosis, white race, epithelial histologic subtypes of OC (serous, endometrioid, mucinous, and Brenner tumor), number of lymph nodes examined (<12), and radiotherapy were significantly associated with an elevated SPM risk. The DCA revealed that the net benefit obtained by our proposed model was higher than the all-screening or no-screening scenarios within a wide range of risk thresholds (1% to 23%). Conclusion The competing risk nomogram can be potentially helpful for assisting physicians in identifying patients with different risks of SPMs and scheduling risk-adapted clinical management. More comprehensive data on treatment regimens and patient characteristics may help improve the predictability of the risk model for SPMs. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/Image_4_Risk_Prediction_of_Second_Primary_Malignancies_in_Primary_Early-Stage_Ovarian_Cancer_Survivors_A_SEER-Based_National_Population-Based_Cohort_Study_tif/19794946Test |
| DOI: | 10.3389/fonc.2022.875489.s004 |
| الإتاحة: | https://doi.org/10.3389/fonc.2022.875489.s004Test https://figshare.com/articles/figure/Image_4_Risk_Prediction_of_Second_Primary_Malignancies_in_Primary_Early-Stage_Ovarian_Cancer_Survivors_A_SEER-Based_National_Population-Based_Cohort_Study_tif/19794946Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.7E8BC667 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2022.875489.s004 |
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