دورية أكاديمية
Real-world observational study to capture practice pattern of controlled ovarian stimulation in the in vitro-fertilization and embryo transfer or intracytoplasmic sperm injection-2
| العنوان: | Real-world observational study to capture practice pattern of controlled ovarian stimulation in the in vitro-fertilization and embryo transfer or intracytoplasmic sperm injection-2 |
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| المؤلفون: | Sharma, Vivek, Dave, Vishal, Mehta, Sonal, Shah, Ankita |
| المساهمون: | Intas Pharmaceuticals Limited |
| المصدر: | International Journal of Reproduction, Contraception, Obstetrics and Gynecology; Vol 11, No 11 (2022): November 2022; 2967-2973 ; 2320-1789 ; 2320-1770 |
| بيانات النشر: | Medip Academy |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | COS, rFSH, In vitro-fertilization, Controlled ovarian stimulation |
| الوصف: | Background: The objective of the study was to evaluate the practice patterns of controlled ovarian stimulation (COS) in patients who underwent in vitro-fertilization and embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI).Methods: In REAL-COS (REAL-world observational study to capture practice pattern of COS in IVF-ET/ ICSI cycle) study, data was collected by 138 clinicians across India between April 2021 and March 2022 in a retrospective manner.Results: Data of 1651 subfertility female patients were evaluated. The mean (SD) age was 31.8 (3.9) years and majority (77.8%) of the patients were aged <35 years. Obese patients constituted 28.1% of the total population. The majority (79.5%) of the patients had primary subfertility and the polycystic ovarian syndrome (PCOS) was the most (27.8%) common cause of subfertility. Nearly equal percent of patients were treated with frozen or fresh embryo transfer. Most (~96%) of the patients received GnRH antagonist protocol wherein cetrorelix acetate was the most common drug (98.7%) while ~4% patients received GnRH agonist protocol wherein luprorelin was the most common one (83%). The most commonly used gonadotropin was recombinant follicle stimulating hormone alone therapy (rFSH, 49.2%). Majority (51.8%) of the patients were initiated at 225 IU dose of gonadotropin for COS. For ovulation trigger, human chorionic gonadotropin (hCG) was used in majority (59%) of the cases. Treatment with rFSH alone therapy resulted in max mean no. of oocytes and mean metaphase-II oocytes as compared with other treatments.Conclusions: This real-world observational study reports primary subfertility as the major reason for IVF-ET/ICSI in the study population. The GnRH antagonist protocol was followed by most of the clinicians participating in this study. rFSH was the most commonly used gonadotropin. rFSH alone therapy yielded the greatest number of oocytes and metaphase II oocytes versus other treatments. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.ijrcog.org/index.php/ijrcog/article/view/12299/7623Test; https://www.ijrcog.org/index.php/ijrcog/article/downloadSuppFile/12299/11716Test; https://www.ijrcog.org/index.php/ijrcog/article/view/12299Test |
| DOI: | 10.18203/2320-1770.ijrcog20222641 |
| الإتاحة: | https://doi.org/10.18203/2320-1770.ijrcog20222641Test https://www.ijrcog.org/index.php/ijrcog/article/view/12299Test |
| حقوق: | Copyright (c) 2022 International Journal of Reproduction, Contraception, Obstetrics and Gynecology |
| رقم الانضمام: | edsbas.7E806DC7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.18203/2320-1770.ijrcog20222641 |
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