دورية أكاديمية
Importance of Abnormal Chloride Homeostasis in Stable Chronic Heart Failure
| العنوان: | Importance of Abnormal Chloride Homeostasis in Stable Chronic Heart Failure |
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| المؤلفون: | Grodin, Justin L., Verbrugge, Frederik H., Ellis, Stephen G., Mullens, Wilfried, Testani, Jeffrey M., Tang, W. H. Wilson |
| سنة النشر: | 2016 |
| المجموعة: | Document Server@UHasselt (Universiteit Hasselt) |
| مصطلحات موضوعية: | chloride, electrolyte imbalances, heart failure, sodium |
| الوصف: | Background—The aim of this analysis was to determine the long-term prognostic value of lower serum chloride in patients with stable chronic heart failure. Electrolyte abnormalities are prevalent in patients with chronic heart failure. Little is known regarding the prognostic implications of lower serum chloride. Methods and Results—Serum chloride was measured in 1673 consecutively consented stable patients with a history of heart failure undergoing elective diagnostic coronary angiography. All patients were followed for 5-year all-cause mortality, and survival models were adjusted for variables that confounded the chloride–risk relationship. The average chloride level was 102±4 mEq/L. Over 6772 person-years of follow-up, there were 547 deaths. Lower chloride (per standard deviation decrease) was associated with a higher adjusted risk of mortality (hazard ratio 1.29, 95% confidence interval 1.12–1.49; P ; This research was supported by grants from the National Institutes of Health and the Office of Dietary Supplements (R01HL103931, P20HL113452). The GeneBank study has been supported by National Institutes of Health (NIH) grants P01HL076491, P01HL098055, and R01HL103866 and the Cleveland Clinic Clinical Research Unit of the Case Western Reserve University CTSA (UL1TR 000439). Reagents for chemistry and BNP measurements were provided by Abbott Laboratories. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1941-3289 |
| العلاقة: | CIRCULATION-HEART FAILURE, 9(1) (Art N° e002453); http://hdl.handle.net/1942/23641Test; 000368620100001 |
| DOI: | 10.1161/CIRCHEARTFAILURE.115.002453 |
| الإتاحة: | https://doi.org/10.1161/CIRCHEARTFAILURE.115.002453Test http://hdl.handle.net/1942/23641Test |
| حقوق: | © 2015 American Heart Association, Inc ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.7E67BF67 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19413289 |
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| DOI: | 10.1161/CIRCHEARTFAILURE.115.002453 |