دورية أكاديمية
GSH/pH-Sensitive Poly(glycerol sebacate dithiodiglycolate) Nanoparticle as a Ferroptotic Inducer through Cooperation with Fe 3+
| العنوان: | GSH/pH-Sensitive Poly(glycerol sebacate dithiodiglycolate) Nanoparticle as a Ferroptotic Inducer through Cooperation with Fe 3+ |
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| المؤلفون: | Yi-Sheng Jiang, Cheng-Rung Huang, Chang-Shi Chen, Jeng-Shiung Jan |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Cell Biology, Molecular Biology, Physiology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, two reactions lead, transferrin receptor 1, prepared via nanoprecipitation, glycerol sebacate dithiodiglycolate, experiment also showed, inhibiting lipid peroxidation, glutathione peroxidase 4, 3 +, pgsdtg nps played, pgsdtg nps ), dual sensitive fe, lipid peroxidation, pgsdtg nps, vivo <, shortened lifespan, sensitive poly, results indicated, released fe |
| الوصف: | Ferroptosis is an iron-dependent, non-apoptotic cell death induced by an overload of iron initiated through Fenton and Haber–Weiss reactions. These two reactions lead to lethal levels of intracellular reactive oxygen species (ROS) and lipid peroxidation. In contrast, glutathione (GSH) and glutathione peroxidase 4 (GPX4) suppress ferroptosis by inhibiting lipid peroxidation. Herein, the ferric ion (Fe 3+ ) carriers, poly(glycerol sebacate dithiodiglycolate) nanoparticles (PGSDTG NPs), were prepared via nanoprecipitation. The GSH/pH-dual sensitive Fe 3+ /PGSDTG NPs would disintegrate via the cleavage of disulfide and ester bonds in the presence of GSH and acidic conditions. The cleaved polymer segments along with released Fe 3+ rendered cancer cells showing ferroptosis characteristics including ROS production, transferrin receptor 1 (TfR1) expression, and iron accumulation after treatment with Fe 3+ /PGSDTG NPs. The PGSDTG NPs played an important role in ferroptosis by triggering the oxidation of intracellular GSH and reducing the GPX4 expression. An in vivo experiment also showed that Caenorhabditis elegans (C. elegans) exhibited a shortened lifespan after treatment with NPs. These results indicated that the PGSDTG NPs were potential GSH/pH-sensitive metal ion carriers for anticancer treatment by inducing ferroptosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/GSH_pH-Sensitive_Poly_glycerol_sebacate_dithiodiglycolate_Nanoparticle_as_a_Ferroptotic_Inducer_through_Cooperation_with_Fe_sup_3_sup_/24973117Test |
| DOI: | 10.1021/acsapm.3c01770.s001 |
| الإتاحة: | https://doi.org/10.1021/acsapm.3c01770.s001Test https://figshare.com/articles/journal_contribution/GSH_pH-Sensitive_Poly_glycerol_sebacate_dithiodiglycolate_Nanoparticle_as_a_Ferroptotic_Inducer_through_Cooperation_with_Fe_sup_3_sup_/24973117Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.7DAD6917 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsapm.3c01770.s001 |
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